36 37 Background: Analysing variant antigen gene families on a population scale is a 38 difficult challenge for conventional methods of read mapping and variant calling due 39 to the great variability in sequence, copy number and genomic loci. In African 40 trypanosomes, hemoparasites of humans and animals, this is complicated by variant 41 antigen repertoires containing hundreds of genes subject to various degrees of 42 sequence recombination. Findings: We introduce Variant Antigen Profiler 43 (VAPPER), a tool that allows automated analysis of variant antigen repertoires of 44 African trypanosomes. VAPPER produces variant antigen profiles for any isolate of 45 the veterinary pathogens Trypanosoma congolense and Trypanosoma vivax from 46 genomic and transcriptomic sequencing data and delivers publication-ready figures 47 that show how the queried isolate compares with a database of existing strains.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
334 Leonard St
Brooklyn, NY 11211
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.