Nutraceuticals are the pharmaceutically blended products that possess both nutritional as well as the medicinal value. Such a product is designed to improve the physical health, fight against day-to-day challenges such as stress, increase longevity, etc. Nowadays, emphasis is given to those herbs which are used as food and medicine due to its greater acceptance. Due to dynamic action, the popularity of nutraceuticals among people as well as healthcare providers has been increased over medicines and health supplements. This review documents herbs with a wide variety of therapeutic values such as immunity booster, antidiabetic, anticancer, antimicrobial, and gastroprotective. These herbs could be better options to formulate as nutraceuticals. Several nutraceuticals are described based on their availability as food, chemical nature, and mechanism of action.
BackgroundThe objective of the present study is to evaluate the gastroprotective activity of Paederia foetida L. leaf for gastric ulcer.MethodsThe methanol extract of P. foetida L. leaves at two different dose levels was investigated for gastroprotective potential by using Indomethacin-pylorus ligation, alcohol induced and water immersion stress induced model in rats. In vitro DPPH* radical scavenging activity and western blot analysis of stomach tissue from pylorus ligatures rats were also carried out. HPTLC analysis was done to understand the phyto-pharmacological relationship.ResultsMethanol extract at a dose level of 100 mg/kg and 200 mg/kg body weight showed 72 and 78 % ulcer protection when compared to negative control whereas reference drug shown 82 % protection in Indomethacin-pylorus ligation model. Further, methanol extract also showed protective effect against 70 % v/v ethanol and stress induced gastric ulcer model. About 84 % protection as compared to cimetidine (85 %) was seen in western blot analysis of stomach tissue from pylorus ligatures rats. HPTLC analysis of methanol extract of P. foetida L. confirmed the presence of β-sitosterol. In DPPH* radical scavenging activity, the IC50 value was observed to be 43.52 μg/ml.ConclusionsThese observations established the traditional claim and thus Paederia foetida could be a potent gastroprotective agent for use in future. The gastroprotective activity might be mediated by the Nrf2 mediated antioxidant and anti secretory effects.
The aim of this study was to quantify the secondary metabolites of aqueous extract of root of Clerodendrum serratum. The root of Clerodendrum serratum was extracted by using water. The yield of aqueous extract was 10%w/w. The total phenolic, flavonoid, saponin and alkaloidal content determined by spectrophotometric method. The amount of total phenolic in extracts was determined in comparison with the gallic acid, whereas total flavonoid, saponin, alkaloid content was estimated corresponding to rutin, diosgenin and atropine respectively. The phenolic, flavonoid, saponin and alkaloidal content of aqueous root extract of Clerodendrum serratum were found to be 134.4mg/g, 67.67mg/g, 38.2mg/g and 12.67mg/g respectively. The presence of such important metabolites in C. serratum indicates its therapeutic importance in man and animal.
Apocynin (APO) is a known multi-enzymatic complexed compound, employed as a viable NADPH oxidase (NOX) inhibitor, extensively used in both traditional and modern-day therapeutic strategies to combat neuronal disorders. However, its therapeutic efficacy is limited by lower solubility and lesser bioavailability; thus, a suitable nanocarrier system to overcome such limitations is needed. The present study is designed to fabricate APO-loaded polymeric nanoparticles (APO-NPs) to enhance its therapeutic efficacy and sustainability in the biological system. The optimized APO NPs in the study exhibited 103.6 ± 6.8 nm and −13.7 ± 0.43 mV of particle size and zeta potential, respectively, along with further confirmation by TEM. In addition, the antioxidant (AO) abilities quantified by DPPH and nitric oxide scavenging assays exhibited comparatively higher AO potential of APO-NPs than APO alone. An in-vitro release profile displayed a linear diffusion pattern of zero order kinetics for APO from the NPs, followed by its cytotoxicity evaluation on the PC12 cell line, which revealed minimal toxicity with higher cell viability, even after treatment with a stress inducer (H2O2). The stability of APO-NPs after six months showed minimal AO decline in comparison to APO only, indicating that the designed nano-formulation enhanced therapeutic efficacy for modulating NOX-mediated ROS generation.
Objective: The intent of this report was to investigate the effect of aqueous root extract of Clerodendrum serratum L. for antioxidant activity using divergent models, namely, 2,2-diphenyl-1-picrylhydrazyl (DPPH) scavenging assay, superoxide scavenging assay, and ferric reducing antioxidant power (FRAP) assay. Methods:The root of C. serratum was extracted using water. The yield of aqueous extract was 10% w/w. The outcome was examined statistically by the regression method. Results:The inhibitory concentration 50% values are 85.43 and 107.59 µg/ml for DPPH radical scavenging assay and superoxide scavenging assay, respectively, whereas FRAP showed a significant reducing power activity with increased concentration of sample. The pilot study showed a significant correlation existed between concentrations of the extract and percentage engrossment of free radicals. Conclusion:The antioxidant property may be corresponding to the polyphenols and flavonoids adjacent in the extract. These results clearly revealed that C. serratum might be effective against diseases analogous with free radical mediated.
Probiotics are known as the live microorganisms which upon adequate administration elicit a health beneficial response inside the host by decreasing the luminal pH, eliminating the pathogenic bacteria in the gut as well as producing short chain fatty acids (SCFA). With advancements in research; probiotics have been explored as potential ingredients in foods. However, their use and applications in food industry have been limited due to restrictions of maintaining the viability of probiotic cells and targeting the successful delivery to gut. Encapsulation techniques have significant influence on increasing the viability rates of probiotic cells with the successful delivery of cells to the target site. Moreover, encapsulating techniques also prevent the live cells from harsh physiological conditions of gut. This review discusses several encapsulating techniques as well as materials derived from natural sources and nutraceutical compounds. In addition to this, this paper also comprehensively discusses the factors affecting the probiotics viability and evaluation of successful release and survival of probiotics under simulated gastric, intestinal conditions as well as bile, acid tolerant conditions. Lastly applications and challenges of using encapsulated bacteria in food industry for the development of novel functional foods have also been discussed in detail too. Future studies must include investigating the use of encapsulated bacterial formulations in in-vivo models for effective health beneficial properties as well as exploring the mechanisms behind the successful release of these formulations in gut, hence helping us to understand the encapsulation of probiotic cells in a meticulous manner.
The halophyte Limonium stocksii (Boiss) Kuntze belongs to the family Plumbaginaceae. In the present work, pharmacognostic studies of this medicinal halophyte was attempted which included physicochemical, phytochemical, macroscopic, microscopic studies and organoleptic evaluation. The plant powder characteristics were also elucidated. The physicochemical analyses were done by using WHO recommended parameters such as loss on drying, ash values (total ash, water soluble ash, acid insoluble ash, sulphated ash, carbonated ash, nitrated ash), extractive values. The qualitative phytochemical analysis revealed the presence of saponins, steroids and coumarins in maximum amount in crude as well as in various solvent extracts. The morphological studies exhibited the organoleptic and surface characteristics of the plant and its parts. The microscopic study showed the presence of various characteristics of whole plant like palisade tissue, metaxylem, protoxylem, phloem showed companion cells, bicollateral type of vascular bundles, parenchyma, rosette calcium oxalate crystals and paracytic stomata. The pharmacognostic characters enlisted in this study will help in identification of the crude drug; the standardization parameters laid down will ensure the efficacy of drug and also distinguish the drug from its adulterants. The distinguishing characters will also be helpful for the preparation of monograph of this halophytic plant
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