No abstract

Our analysis indicated that higher DII is significantly correlated with cancer risk. More prospective studies with large sample sizes, involving more ethnic groups and different cancer types, are required in the future. This review was registered with PROSPERO as CRD42017077075.

Purpose This paper aims to investigate how top management service commitment (TSC) affects two dimensions of new product development (NPD), speed and product innovativeness, and to examine how dysfunctional competition moderates the effects in emerging economies. Design/methodology/approach Data were collected from 151 high-tech manufacturing firms in China. In one firm, two different top managers were surveyed to reduce the common method variance. The authors used the seemingly unrelated regression approach to test the hypotheses. Findings First, TSC negatively influences product innovativeness, an effect that dysfunctional competition attenuates. Second, despite not being significantly positive as hypothesized, the direct effect of TSC on NPD speed remains positive when dysfunctional competition is high rather than low. Third, the findings reveal that product innovativeness increases firm performance, but NPD speed shows no similar effect. Practical implications First, top managers should pay attention to the synergistic effect between industrial services and product businesses. Second, manufacturing firms in developing countries need to implement servitization when facing unlawful competitive behaviors. Originality/value In literature, the effect of industrial services on NPD is unclear. The present study enriches literature by connecting servitization with NPD and by focusing on the importance of top managers to the implementation of servitization. In addition, the authors extend the servitization literature to emerging economies and thereby provide significant insights into this context.

Purpose The purpose of this paper is to explore the antecedents of demand-side search in service strategy of manufacturing firms. In particular, this study examines whether service-oriented human resource management (HRM) practices promote demand-side search by enhancing firms’ market capability as well as how top management service commitment and service organizing moderates this relationship in manufacturing firms. Design/methodology/approach To test this research model, this study obtains survey data from two distinct informants of 279 manufacturing firms in China. Data were collected applying a standard questionnaire in a five-point Likert scale. The hypotheses are tested using hierarchical regression analysis and partial least squares. Findings Results show that service-oriented HRM practices can promote demand-side search by enhancing firms’ market capability. Furthermore, it is found that top management service commitment negatively moderates the relationship between service-orientated HRM practices and demand-side search, while service organizing positively moderates this relationship. Research limitations/implications Depending on cross-sectional subjective data for the core variables and the choice of Chinese manufacturing firms limit the capacity to generalize the findings. Practical implications This research suggests that service-oriented HRM practices are important drivers of demand-side search activities and to take advantage of service-oriented HRM practices, firms should commit to market capability development. In addition, it is better to match service-oriented HRM practices with other service-oriented organizational parameters such as top management service commitment and service organizing. Originality/value The study highlights the crucial role of service-oriented HRM practices in demand-side search, the mediating role of market capability and the moderating role of other service-oriented organizational parameters such as top management service commitment and service organizing. This study advances research on knowledge search, servitization and strategic HRM.

Endometriosis is a common multi‐factorial gynaecological disease. Recent studies have revealed that long non‐coding RNAs (lncRNAs) are involved in the pathogenesis of endometriosis. In the present study, the expression profiles of lncRNAs in 6 pairs of endometriosis ectopic endometrium (ecEM) and eutopic endometrium (euEM) tissues were analysed by RNA sequencing. From the profiles, LINC01116 was found to be up‐regulated in ecEM tissues compared to euEM tissues and was verified by quantitative real‐time PCR (qRT‐PCR). Then, functional experiments demonstrated that LINC01116 promoted the proliferation and migration of ectopic primary endometrial stromal cells (ESCs), while miR‐9‐5p exerted the opposite effects. Dual‐luciferase reporter assays verified that LINC01116 directly sponged miR‐9‐5p and relieved the suppression of its target, Forkhead box protein P1 (FOXP1). Rescue experiments further demonstrated that LINC01116 could promote proliferation and migration of ESCs by targeting FOXP1 via sponging miR‐9‐5p. Overall, our study illuminates that LINC01116 promotes the progression of endometriosis through the miR‐9‐5p/FOXP1 axis. This finding provides a novel therapeutic target for patients with endometriosis.