L-carnitine is a co-factor of the enzymatic system involved in long chain fatty acid transport across the mitochondrial membrane. L-carnitine also modulates the metabolism of coenzyme-A (CoA). The functions of L-carnitine in skeletal muscle are critical to sustaining normal bioenergetics during exercise. Therefore, it is not surprising that the use of supplementary carnitine to improve physical performance has become widespread in recent years. Carbonic anhydrases (CAs, EC 4.2.1.1) are widespread enzymes in all organisms, catalyzing CO 2 hydration to bicarbonate and protons. It is known that CA inhibition alters skeletal muscle contractile properties, utilization of metabolic substrates, and accumulation of metabolic intermediates and end products, especially during exercise. In this study, changes in carbonic anhydrase (CA) levels due to exercise and hyperthermic stress in rats were investigated. For this purposes, 24 healthy Spraque Dawley male rats were divided into four groups: Exercise group 1 (at 38°C), Exercise group 2 (control group at 28°C), L-carnitine + Exercise group 3 (at 38°C), L-carnitine + Exercise group 4 (L-carnitine + control group at 28°C). The results of this study indicated that CA inhibition significantly decreased at L-carnitine + Exercise group 4 (at 28°C) (P<0,01) and Exercise group 1 (at 38°C) (P<0.005). According to L-carnitine + Exercise group 3 (at 38°C). It may be considered that L-carnitine does not have a protective role in exercise done under hyperthermic conditions.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
334 Leonard St
Brooklyn, NY 11211
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.