We report on the enzymatic degradation of 14C-labelled 5',5"-linked dinucleoside triphosphates Gp3A, 2-O-mGp3A, 2'dGp3A, 2',3"ddGp3A and m7Gp3A in rat liver nuclei. The 2'-desoxy- and 2',3'-didesoxy compounds are poorer substrates than the other cap-structured dinucleotides investigated.
We report on the chemical preparation of 14C-labeled P1, P3-(5′-guanosyl-5″-adenosyl) triphosphate (1) which is the parent compound of 5′-terminal cap structures of most eukaryotic mRNAs.Incubation experiments of cap (1)- and non cap-structured nucleotides as Ap2A (2) as well as their ribose ring opened derivatives (3, 4) with rat liver subcellular fractions show that capdegrading nucleases being able to unblock 5′ termini are present in nuclei but not in mitochondria.
THis is the latest of the series of sumptuous volumes which we owe to Professor Gustaf Retzius of Stockholm. To say that it fully maintains the standard of the volumes which have preceded it, is the highest praise which can be accorded to it. Of the seven articles which it contains, that upon the body-form of the fwtus at different stages of its development is likely to attract the most attention. The illustrations in connection with this article are of singular beauty and most suggestive. Professor Retzius has already given descriptions and photographs of the brains of certain people who have attained celebrity during life. In this volume the brain of a statesman is carefully described and delineated. D. J. C.
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