Objective: This study was designed to compare the effect of Aloe vera gel with aspirin and celecoxib on platelet aggregation. Study Design: Comparative Study. Setting: Post graduate Medical Institute Lahore, Children Hospital, Lahore. Period: September 2015 to September 2016. Material & Methods: Blood was withdrawn from anti-cubital vein, complete blood count was checked, platelet rich plasma was prepared by centrifuging citrated whole blood and then incubated with Aloe vera low (AVL), Aloe vera high (AVH), aspirin and celecoxib for 30 minutes at 37C. After adding the agonist arachidonic acid, reading was then taken for 3 minutes and percentage aggregation was recorded. Results: Platelet aggregation with aspirin, AVH and AVL was statistically significantly lower as compared to control and celecoxib groups. Conclusion: This study has demonstrateda dose dependentanti-platelet effect of Aloe vera gel which is comparable to aspirin.
The herbal use for medical purposes is increasing world over. Aloe vera is onesuch herb with established anti-inflammatory action. It has great prospect in terms of replacingtraditional NSAIDS due to better side effect profile on gastrointestinal tract but its effect onplatelet aggregation is what needs to be determined. Objectives: This study was designed tosee the concentration dependent action of Aloe vera gel on platelet aggregation. Study Design:Comparative study. Setting: Post Graduate Medical Institute Lahore, Children Hospital Lahore.Duration of Study: One Year. Methodology: This study was conducted on healthy volunteersselected from staff and students of Ameer-ud-din Medical College. After determining baselineHb and platelet counts, PRP was prepared and then incubated with 2 different concentrationsof Aloe vera low (AVL) and Aloe vera high (AVH) for 30 minutes. Aggregation was stimulatedby adding the agonist arachidonic acid. Light transmission aggregometer was used to recordplatelet aggregation activity graphically for 3 minutes. Results: The data was analyzed usingSPSS version 20. Kruskal Wallis H test was performed to compare the platelet aggregation,which revealed that platelet aggregation with AVL and AVH were statistically significantly lower,amounting to 25.89% and 16.72% respectively as compared to 88.28% observed with control.Conclusion: This study has established in vitro anti-platelet effect of Aloe vera which is dosedependent.
Objective: To assess the diagnostic accuracy of mean arterial pressure in second trimester for prediction of pre-eclampsia in females. Study Design: Cross-sectional study. Setting: Department of Obstetrics & Gynecology Unit III, Allied hospital, Faisalabad. Period: October 2016 to September 2017. Material & Methods: Total 386 patients were enrolled after obtaining informed consent. Booked females of age 18-40 years, parity<5 presenting at gestational age >16 weeks (on LMP) for antenatal checkup were included in study. Patients with multiple gestation (on medical record and USG), Females with chronic hypertension (BP≥140/90mmHg), chronic or gestational diabetes (BSR>186mg/dl), Females having oligohydramnios (AFI<5cm) or polyhydramnios (AFI>21cm) on USG, females having abnormal placental implantation or placental abruption (on USG) were excluded. The mean age of the patients was 28.59±6.93 years. The MAP of the patients was 94.88±14.68 mmHg. Results: The sensitivity, specificity and diagnostic accuracy of MAP was 92.89%, 89.12% and 91.45% respectively taking preeclampsia as gold standard. Conclusion: The mean arterial pressure in second trimester is very effective and useful screening method for prediction of preeclampsia with high values of sensitivity, specificity and diagnostic accuracy.
ABSTRACT:The herbal use for medical purposes is increasing world over. Aloe vera is one such herb with established anti-inflammatory action. It has great prospect in terms of replacing traditional NSAIDS due to better side effect profile on gastrointestinal tract but its effect on platelet aggregation is what needs to be determined. Objectives: This study was designed to see the concentration dependent action of Aloe vera gel on platelet aggregation. Study Design: Comparative study. Setting: Post Graduate Medical Institute Lahore, Children Hospital Lahore. Duration of Study: One Year. Methodology: This study was conducted on healthy volunteers selected from staff and students of Ameer-ud-din Medical College. After determining baseline Hb and platelet counts, PRP was prepared and then incubated with 2 different concentrations of Aloe vera low (AVL) and Aloe vera high (AVH) for 30 minutes. Aggregation was stimulated by adding the agonist arachidonic acid. Light transmission aggregometer was used to record platelet aggregation activity graphically for 3 minutes. Results: The data was analyzed using SPSS version 20. Kruskal Wallis H test was performed to compare the platelet aggregation, which revealed that platelet aggregation with AVL and AVH were statistically significantly lower, amounting to 25.89% and 16.72% respectively as compared to 88.28% observed with control. Conclusion: This study has established in vitro anti-platelet effect of Aloe vera which is dose dependent. Key words:Aloe Vera, Anti-platelet.
To assess the effect of low and high dose of glycyrrhizin on body weight, fasting blood sugar level (FBSL), serum insulin and glycemic indices in high fat diet induced type 2 diabetic rats. METHODS:In this experimental study with intervention period of 34 weeks, rats were grouped into four experimental groups; Group-A: normal control; Group-B: diabetic control; Group-C: glycyrrhizin-150 and Group-D: glycyrrhizin-300. Diabetes mellitus was induced in rats by giving high fat diet with injection dexamethasone. At 32 weeks, body weight, FBSL, serum insulin, Homeostatic Model Assessment of Insulin Resistance (HOMA-IR), Homeostatic Model Assessment of beta cells (HOMA-β) and Quantitative Insulin Sensitivity Check Index (QUICKI) were estimated. Two experimental groups received glycyrrhizin 150 mg/kg and 300 mg/kg per oral per day till completion of 34 weeks in addition to the high fat diet. At 34 weeks all the parameters were re-estimated. RESULTS: It was observed that both doses of glycyrrhizin significantly reduced FBSL and insulin levels in group-C (95.00±8.23 mg/dl, 671.60±55.51 µIU/ml) and group-D (94.00±6.27 mg/dl, 675.00±44.96 µIU/ml) as compared to group-B (236.10±13.26 mg/dl, 1052.80±37.82 µIU/ml) [p-value<0.001] at 34 weeks. HOMA-IR decreased [group-C (157.62±19.39) and group-D (157.03±18.21) vs group-B (613.79±49.91)] whereas HOMA-β [group-C (2498.23±299.58) and group-D (2526.24±150.65) vs group-B (1546.87±106.81)] and QUICKI increased [group-C (0.208±0.00) and group-D (0.208±0.002) vs group-B (0.185±0.001)] (P-value<0.001). Body weight decreased insignificantly in group-C (344.00±30.21mg) (P-value>0.05) but significantly in group-D (293.20±42.54) as compared to group-B (372.00±24.03) [P-value<0.001]. CONCLUSION: Glycyrrhizin effectively improves glycaemic control in rat model of type 2 diabetes mellitus.
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