Pregnancy is a diabetogenic state manifested by insulin resistance and hyperglycaemia. The age group at risk of getting gestational diabetes is between 20 and 39 years in 96.8% of cases. Gestational diabetes is the development of symptoms and signs of diabetes mellitus during pregnancy and the glucose level reverting to normal during puerperium. Depending on the type of population and the diagnostic criteria used, gestational diabetes is said to complicate 1-16% of all pregnancies. Many researchers in American, European and Asian surveys have reported 3-6% of prevalence. Compared with white European women, the prevalence rate for GD is increased approximately elevenfold in women from the Indian subcontinent, eightfold in South East Asia, sixfold and threefold in Arab and black Afro-Caribbean women, respectively. Such figures draw a potent clinical interest towards gestational diabetes (GD), and this chapter attempts to highlight some major aspects of GD in respect to both the mother and the foetus or the newborn specially emphasizing on its management as per the World Health Organization (WHO) and International Federation of Gynaecology and Obstetrics (FIGO).
The current study was focused on the design, development, and evaluation of the fast-dissolving tablet of a polyherbal combination of curcumin, quercetin, and rutin. These herbal drugs are poorly water-soluble.
The center of attention for this study is to provide quick onset of action, improved bioavailability, and
increased patient compliance for administering a tablet. All parameters of Polyherbal Fast dissolving
tablets were evaluated, and all were found within the official range. Drug content ranges between 90
to 105%. The formulation PHT24 containing a high concentration of Crosspovidone enhanced the drug
release up to 94% within 5 minutes compared with the control. The optimized formula PHT24 showed
favorable drug dissolve characteristics with better mouth feel and acceptable fast-dissolving properties. It
was also observed that all formulations were acceptable with reasonable limits of the standard required
for fast-dissolving tablets. The study also reveals that the Superdisintegrants used were effective in low or
high concentrations. It was concluded that fast dissolving tablets with enhanced dissolution rates could
be made using selected Superdisintegrants
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