Detection and removal of lipopolysaccharides (LPS) from food and pharmaceutical preparations is important for their safe intake and administration to avoid septic shock. We have developed an abiotic system for reversible capture, removal, and detection of LPS in aqueous solutions. Our system comprises long C18 acyl chains tethered to FeO/Au/FeO nanoflowers (NFs) that act as solid supports during the separation process. The reversible LPS binding is mediated by facile hydrophobic interactions between the C18 chains and the bioactive lipid A component present on the LPS molecule. Various parameters such as pH, solvent, sonication time, NF concentration, alkane chain length, and density are optimized to achieve a maximum LPS capture efficiency. The NFs can be reused at least three times by simply breaking the NF-LPS complexes in the presence of food-grade surfactants, making the entire process safe, efficient, and scalable. The regenerated particles also serve as colorimetric labels in dot blot bioassays for simple and rapid estimation of the LPS removed.
Nanomedicine is the subfield of nanotechnology which deliver a promising diagnostic as well as treatment of lethal diseases like cancer. By interacting with biological molecules, therefore at nanoscale, nanotechnology opens up a vast field of resear ch and application. These are the medicine which have very small in size or present in molecular level. There are more than one component of a nanomedicine which range from advance diagnostic devices, advance drug delivery vehicle including nanobots which are able to perform specific artificial surgeries with the ultimate degree of precision, which is never achieved in past .Future nanomedicine will be capable to detect the lethal diseases like cancer in very early stage. There will be al so a possibility in future that with the help Nanomedicine are able to treat the genetic diseases or genetic disorder by targeting or repairing specific genes, tissue and cells which are responsible for these type of disorder with the help of nanomedicines.
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