A method for the direct oxidation
of various N-aryl tetrahydroisoquinolines and isoindolines
to the corresponding
lactams using α-angelica lactone as a catalyst was developed.
The utility of the method was further demonstrated by synthesis of
indoprofen and indobufen.
Oxidation of benzylic sp3 C–H bonds of isochromans and phthalans to isocoumarins and phthalides has been achieved by employing α-angelica lactone as an organocatalyst.
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