• An efficient method was proposed to prepare perpendicular graphene nano-sheets in flexible sensor electrode. • The nanostructure in carbon electrode was fabricated to further enhance the sensitivity of sensor device using a simple method. • The capacitance showed high performance within only 50-μm dielectric thickness, and an exciting phenomenon of decreasing in capacitance was analyzed. ABSTRACT Graphene-based materials on wearable electronics and bendable displays have received considerable attention for the mechanical flexibility, superior electrical conductivity, and high surface area, which are proved to be one of the most promising candidates of stretching and wearable sensors. However, polarized electric charges need to overcome the barrier of graphene sheets to cross over flakes to penetrate into the electrode, as the graphene planes are usually parallel to the electrode surface. By introducing electron-induced perpendicular graphene (EIPG) electrodes incorporated with a stretchable dielectric layer, a flexible and stretchable touch sensor with "in-sheet-chargestransportation" is developed to lower the resistance of carrier movement. The electrode was fabricated with porous nanostructured architecture design to enable wider variety of dielectric constants of only 50-μm-thick Ecoflex layer, leading to fast response time of only 66 ms, as well as high sensitivities of 0.13 kPa −1 below 0.1 kPa and 4.41 MPa −1 above 10 kPa, respectively. Moreover, the capacitance-decrease phenomenon of capacitive sensor is explored to exhibit an object recognition function in one pixel without any other integrated sensor. This not only suggests promising applications of the EIPG electrode in flexible touch sensors but also provides a strategy for internet of things security functions.

We propose a single layer all-dielectric metasurface lens to simultaneously convert and focus an incident linear polarization into a radial beam with high efficiency and high numerical aperture (NA). It shows a better focusing property compared with the linearly polarized metasurface lens for high NA. A tight spot size (0.502λ) is achieved for the NA = 0.94. Additionally, the emergent polarization can in principle be switched flexibly between radially and azimuthally polarized beams by the adjustment of incident polarization direction. It is expected that our scheme may have potential value in microscopy, material processing, medicine, particles accelerating and trapping, and so on.

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Previous studies have indicated that bone morphogenetic protein 9 (BMP9) can promote the osteogenic differentiation of mesenchymal stem cells (MSCs) and increase bone formation in bone diseases. However, the mechanisms involved remained poorly understood. It is necessary to investigate the specific regulatory mechanisms of osteogenic differentiation that were induced by BMP9. During the process of osteogenic differentiation induced by BMP9, the expression of microRNA-155 (miR-155) exhibited a tendency of increasing at first and then decreasing, which made us consider that miR-155 may have a modulatory role in this process, but the roles of this process have not been elucidated. This study aimed to uncover miR-155 capable of concomitant regulation of this process. mmu-miR-155 mimic (miR-155) was transfected into MSCs and osteogenesis was induction by using recombinant adenovirus expressing BMP9. Overexpressed miR-155 in MSCs led to a decrease in alkaline phosphatase (ALP) staining and Alizarin red S staining during osteogenic differentiation, and reduced the expression of osteogenesis-related genes, such as runt-related transcription factor 2 (Runx2), osterix (OSX), osteocalcin (OCN) and osteopontin (OPN). On protein levels, overexpressed miR-155 markedly decreased the expression of phosphorylated Smad1/5/8 (p-Smad1/5/8), Runx2, OCN and OPN. Luciferase reporter assay revealed Runx2 and bone morphogenetic protein receptor 9 (BMPR2) are two direct target genes of miR-155. Downregulation of the expression of Runx2 and BMPR2, respectively could offset the inhibitory effect of miR-155 in the osteogenesis of MSCs. In vivo, subcutaneous ectopic osteogenesis of MSCs in nude mice showed miR-155 inhibited osteogenic differentiation. In conclusion, our results demonstrated that miR-155 can inhibit the osteogenic differentiation induced by BMP9 in MSCs.

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