In this study, the effects of carbendazim on the thymus in male rats were evaluated. Carbendazim was administered at 0, 150, 300 and 600 mg kg(-1) day(-1) doses by gavage to male rats for 15 weeks. Body weights of rats in all groups were recorded weekly during treatment. At the end of the experiment, the effects of carbendazim on the thymus were investigated histopathologically and morphologically. Also, based on these effects, change in immunolocalization of fibronectin (FN), which is a component of the extracellular matrix, was investigated immunohistochemically. Fibrosis and oedema were observed in the thymus of rats treated with 300 and 600 mg kg(-1) day(-1) doses of carbendazim. Also in this region, an increase in FN density was noted at the end of the immunohistochemical investigation. A decrease was observed in absolute and relative thymus weights of rats treated with carbendazim compared with the control group. While the decrease in absolute thymus weight was statistically significant in rats exposed to carbendazim at the highest dose, the decrease in relative thymus weights was statistically significant for all carbendazim doses.
The purpose of this study was to determine the effects of carbendazim (methyl 2-benzimidazole carbamate) on the some hormone levels and on testis tissue. Carbendazim in the doses of 0, 150, 300, and 600 mg/kg/day were administered (by gavage) to male rats, daily for 15 weeks. At the end of the experiment serum total testosterone and dihydrotestosterone (DHT) levels were analyzed and testis tissues were taken for light and electron microscopic examinations. A statistically significant decrease in total serum testosterone level in rats exposed to carbendazim (dose: 300 and 600 mg/kg/day), compared to the control, was observed. Also, dihydrotestosterone level was significantly decreased in all experimental groups. Histopathologically, carbendazim caused detrimental effects in testis tissues. These effects were vacuolization, disorganization and necrosis in germinal epithelium. In addition, multinucleated giant cells were observed in the lumen of the seminiferous tubules. These pathological findings were supported by electron microscopic examinations. These results suggest that carbendazim, in subchronic exposure, affects testis tissue and androgenic hormone levels.
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