Gastrodia elata
is a famous traditional Chinese herb with medicinal and edible application. In this study, three new polybenzyls, gastropolybenzylols G-I (
1–3
) were isolated from the EtOAc extract of
G. elata.
Their structures were identified by extensive spectroscopic analyses involving HRESIMS, UV, IR, 1D and 2D NMR. Compound
1
showed agonistic effects on MT
1
and MT
2
receptors with agonistic rates of 55.91±4.84% and 165.13±5.65% at the concentration of 0.5 mM, respectively, and an EC
50
value of 76.24
μ
M on MT
2
receptor.
Graphic Abstract
Electronic supplementary material
The online version of this article (10.1007/s13659-019-0213-2) contains supplementary material, which is available to authorized users.
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