Background: Cancer metastasis is the main obstacle to increasing the lifespan of cancer patients. Epithelial-to-mesenchymal transition (EMT) plays a significant role in oncogenic processes, including tumor invasion, intravasation, and micrometastasis formation, and is especially critical for cancer invasion and metastasis. The extracellular matrix (ECM) plays a crucial role in the occurrence of EMT corresponding to the change in adhesion between cells and matrices. Conclusion: SPOCK1 is a critical regulator of the ECM and mediates EMT in cancer cells. This suggests an important role for SPOCK1 in tumorigenesis, migration and invasion. SPOCK1 is a critical regulator of some processes involved in cancer progression, including cancer cell proliferation, apoptosis and migration. Herein, the functions of SPOCK1 in cancer progression are expounded, revealing the association between SPOCK1 and EMT in cancer metastasis. SPOCK1 is a positive downstream regulator of transforming growth factor-β, and SPOCK1-mediated EMT regulates invasion and metastasis through the Wnt/βcatenin pathway and PI3K/Akt signaling pathway. It is of significance that SPOCK1 may be an attractive prognostic biomarker and therapeutic target in cancer treatment.
Reactive power compensation utilizing SVC and STATCOM is the most important method to improve power quality. In this paper, the technical features of SVC and STATCOM are introduced and then a power system in enterprises is used as an example in order to show effectiveness of SVC and STATCOM. Determination of location where SVC and STATCOM should be installed and their capacity is important for enhancement of power system voltage stability. Considering different kind of failure in power grid in enterprises, this paper gives analysis of voltage changes and motor load losses of the power system, on the meantime taking into account of the influence of external grid failure. Based on PSD-BPA software and mathematical model, the optimal design program of reactive power compensation utilizing STATCOM is determined by comparing effectiveness of SVC and STATCOM. Test results show very encouraging result.
Considering different kind of external grid failures, this paper gives analysis of voltage fluctuation and flicker of large petrochemical enterprise grid. Trajectory-based time-domain dynamic simulation method is used to analyze problems of transient voltage security. A strategy for the application of STATCOM is proposed in order to improving electric power quality. The total loss of motor load of the whole system is counted and buses are sorted according to sensitivity analysis to ascertain installing sites of STATCOM. Then the optimal capacity of STATCOM can be gained by the way of solving linear programming model,which is suitable for transient voltage security under multi-faults. Test simulations show very encouraging result.
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