Alopecia areata (AA) is the most frequent, localized, nonscarring hair loss that affects any hair bearing skin. 1 The lifetime risk of AA in the general population is about 2%. 2 It most commonly presents by single or multiple distinct, well-defined round or oval patches of hair loss on the scalp or body, the disease might involve the whole scalp (alopecia totalis) or the total body (alopecia universalis). 3 Alopecia areata is a complex disease where many factors assumed to be involved in its development, such as autoimmunity, genetic constitution, and emotional and environmental stress. 4 Cells infiltrating the skin after immunological and/or nonimmunological
Background:Acne vulgaris (AV): is the most frequent dermatologic illness and is the chronic, multifactoral, inflammatory disease of the pilosebaceous unit. Aim: to compare the dynamic balance between thiol/disulfide and the balance of healthy individuals in AV sufferers. Methods: This research has been performed on 40 individuals who have been clinically diagnosed with AV. Furthermore, 40 seemingly healthy people of matching sex and age are controlled. Each patient had a thorough history, a comprehensive clinical examination and a laboratory study for: Total Thiol and thiol disulphide serum level. Results & Findings: The age varied from 16 to 31 years with mean ± SD = (22.40±4.35) years, while the control age was between 16 and 31 years with mean ±SD = (23.83±4.99) years, with no significant statistical differences (p=0.288) between both groups. This age was considered to have been between 16 and 31 years. Comparative for serum total thiol, serum thiol disulfide and their ratio between the two groups examined. The serum total thiol (p<0,001) and serum thiol disulfide (p<0,001) in the AV group were significantly increased as compared to the control group. Although the total thiol/thiol disulfide ratio (p<0.001) in AV group has decreased considerably compared with the control group.
Onychomycosis is a common nail disease, especially in older patients.Various treatment options are currently available for onychomycosis; however, their limitations include high failure rates, time-consuming nature, high cost, and high risk of drug interactions. Objective: To evaluate the efficacy of onychomycosis treatment with a long-pulsed 1064-nm Nd:YAG laser. Patients and Methods: ten patients were assessed. The study involved treatment with a long-pulsed 1064-nm Nd:YAG laser in two sessions at 4-week intervals. Fungal culture at two media sabourauds dextrose agar with cycloheximide and without cycloheximide and microscopic examination were performed at the start and then one-month after the second session. Results: After two sessions, the mycological test results were negative in eigh 80%. The result showed that the mean improvement percentage was 60.50 %. Side effects were mild and limited to mild pain and delayed nail growth after the laser procedure. Conclusions: Long-pulsed 1064-nm Nd:YAG laser therapy is safe and effective for treating onychomycosis.
Warts are common viral infections of the skin and mucous membranes that are caused by the human papilloma virus (HPV). Warts are prevalent worldwide. Recently, immunotherapy with intralesional antigens or vaccines has been tried for the treatment of common warts with encouraging results. It could lead to resolution without any physical changes or scarring and in addition would augment the host response against the causative agent. The aim of this study is to evaluate the effect of intralesional injection of MMR vaccine with intralesional injection of saline in patients with viral warts. This study was carried out in Dermatology, Venereology and Andrology Department Outpatients Clinics, Benha University Hospitals.This study included 38 patients with viral warts.18 patients were injected with MMR vaccine while 20 patients were injected with saline as control.Approval of Dermatology, Venereology and Andrology Department and Ethics Committee in the Faculty of Medicine, Benha University was taken before preceding the study. Written consent was taken from all participants involved in this study. Comparing between response obtained after MMR injection and saline injection in control group revealed significantly better response in MMR group when compared to control groups (p<0.001 for each).14 patients (77.8%) reached complete response after MMR injection while no patient responsed to saline injection. No significant association was found regarding response of mother warts to recurrence in all studied cases' groups. MMR injection showed significantly better response of mother wart when compared to control group. MMR injection showed significantly better response of other warts when compared to control group.
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