In this paper, we present the incurred sample reanalysis (ISR) data for cefuroxime in various ocular tissues of rabbits. Based on the cefuroxime concentration vs. time profile in various ocular tissues, three chosen time points enabled ISR assessment. Cefuroxime was quantitated in the ocular tissues using a published liquid chromatography–electrospray ionization/tandem mass spectrometry method operated under the multiple reaction‐monitoring mode in positive ion mode. Regardless of the ocular tissue, the linearity range was 12.7–2760 ng/ml with a correlation coefficient (r2) of ≥0.996. All of the ISR samples representing various ocular tissues met the acceptance criteria. To the best of our knowledge, this is the first report showing the ISR of ocular tissues in any species.
Hypolipidemic effect of fruit juice of Hippophae rhamnoides L was evaluated in 1% cholesterol and 10% ground nut oil diet induced hyper cholesteremic models of New Zealand rabbits. The fruit juice at 0.46ml/kg body weight reduced the elevated serum total cholesterol (TC), triglyceride, low density cholesterol (LDL-C), atherogenic index, and C - reactive protein levels on diet induced rabbits. The juice at the same dose significantly enhanced the high density lipoprotein (HDL) in high fat diet (HFD) induced hyperlipidemic rabbits. The reference compound atorvastatin showed significant (p<0.05) effects.
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