The cytotoxic effects of HMN-176 ((E)-4-[[2-N-[4-methoxybenzenesulfonyl] amino] stilbazole] 1-oxide; a newly synthesized compound, were evaluated and compared with those of the clinically used antitumor agents cis-platinum, adriamycin, etoposide, taxol, and vincristine in 22 human tumor cell lines isolated from various organs. HMN-176 exhibited potent cytotoxicity with IC(50) values in the nM range, and the variance of its cytotoxic efficacy was remarkably small. Drug-resistant cell lines also showed low cross-resistance to HMN-176 corresponding to overall resistance indices of less than 14.3. HMN-214 was synthesized as an oral prodrug because of the poor oral absorption of HMN-176 itself. Pharmacokinetic studies showed that HMN-214 was an acceptable oral prodrug of HMN-176. In the in vivo analysis of the schedule-dependency of HMN-214, the repeated administration for over 5 days elicited potent antitumor activity, as expected from the exposure-dependency of the cytotoxicity of HMN-176 and from the cytometric studies. The antitumor activity of HMN-214 against human tumor xenografts was equal or superior to that of clinically available agents, including cis-platinum, adriamycin, vincristine, and UFT without severe toxicity such as neurotoxicity. Because of its good activity in preclinical trials, HMN-214 has entered Phase I clinical trials in the USA.
This paper proposes a new current balancer in single-phase secondary distribution feeders using the three-leg PWM converter. A new control method for the proposed current balancer with the correlation coefficients is also proposed. The basic principle of the proposed current balancer with the proposed control method is discussed in detail, then confirmed by digital computer simulation using PSIM software. A prototype experimental model is constructed and tested to verify the validity and practicability of the proposed current balancer. Fig. 1 shows a circuit diagram of the constructed experimental model of the proposed current balancer in single-phase secondary distribution feeders. The three-leg PWM converter that performs a current balancer is connected in parallel to the loads. The source voltage v S , the load currents i L1 and i L2 are detected, and then the components of the load currents correlative to the source voltage waveform, which correspond to the active currents, are calculated in each feeder by a DSP (digital signal processor: TMS320C6713). The reactive and unbalanced-active components are compensated on the source side. The balanced currents with unity power factor are obtained in each feeder. Fig. 2 shows experimental results for Fig. 1, where the unbalanced loads are connected. Before the current balancer was started, the source currents i S 1 and i S 2 were unbalanced, and their power factors were not unity, respectively. After the current balancer was started, the source currents i S 1 and i S 2 were balanced with the unity power factor in spite of the unbalanced load currents i L1 and i L2 . In the proposed current balancer consisting of the three-leg converter, the active powers on the load side are exchanged in the three-leg converter. Thus only the reactive power flows into the DC capacitor C DC . The required-rating of the DC capacitor C DC can be reduced by one-tenth as compared to that of the previously proposed current balancer. This demonstrates that the proposed current balancer is useful for the practical applications. Fig. 2. Experimental waveforms for the constructed experimental model of Fig. 1 -17 -
SUMMARYThis paper proposes a new current balancer in singlephase three-wire secondary distribution systems using the correlation coefficients. The components of the load currents correlative to the primary side voltage waveform, which correspond to the active currents, are detected in each feeder, then the nonactive and unbalanced-active components are compensated on the source side. The balanced currents with unity power factor are obtained in each feeder. The basic principle of the proposed method is discussed in detail, and then confirmed by digital computer simulation. A prototype experimental system is constructed and tested. Experimental results demonstrate that the balanced source currents with unity power factor are obtained in spite of unbalanced load currents.
This paper proposes a new control method of the current balancer in single-phase three-wire secondary distribution systems using the correlation function. The components of the load currents correlative to the primary side voltage waveform, which correspond to the active currents, are detected in each feeder, then the non-active and unbalancedactive components are compensated on the source side. The balanced currents with unity power factor are obtained in each feeder. The basic principle of the proposed method is discussed in detail, and then confirmed by digital computer simulation. Digital computer simulation results demonstrate that the balanced source currents with unity power factor are obtained in spite of unbalanced load currents.
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