Graphical abstract
Conformational change of His479 side chain in the inverse-agonist-bound RORγt+3SX; (a) at 228 ns and (b) at 230 ns of MD simulations. By the rotation of His side chain, the interactions between His479 and 3SX/Tyr502 are significantly changed.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.