Brain metastases are a common tumour disease, and many cancer patients are prone to developing brain metastases after developing lung, breast and bowel cancer. However, not all parts of cancer can be completely removed, so in most cases, chemotherapy and radiotherapy are required to achieve a cure and prolong life. Stereotactic Body Radiation Therapy is a new radiation therapy technique that has emerged recently. The difference between this technique and conventional radiation therapy is that it requires a relatively high single dose, a higher degree of precision in localisation and better treatment results. When faced with the same treatment as the general population, the elderly are less tolerant of the drugs and radiation, and they are less able to repair the damage caused by the drugs and radiation, which makes it easier for them to die during the treatment process. This is why there are high demands on organ protection, the precision of positioning and dose to the target area in the elderly population when it comes to radiation therapy. This paper presents a short summary of Stereotactic Body Radiation Therapy for the elderly after diagnosis of brain metastases, including clinical response, side effects and organ protection in the elderly. Many of the paper's case data sources and clinical accounts are based on specific facts. To conclude, treating brain metastases is a very long process, and there is not enough time for elderly patients, and the SBRT technique can reduce the treatment time for patients.
Glycoproteins in the Apolipoprotein E (APOE) class have a role in controlling lipid metabolism. In astrocytes, microglia, vascular wall cells, and choroid plexus cells of the central nervous system, it is abundantly expressed. According to the rapid advancement of contemporary medicine, numerous investigations have demonstrated the existence of ApoE in chylomicron (CM), very low density lipoprotein (VLDL), intermediate density lipoprotein (IDL), and certain high-density lipoprotein (HDL). ApoE has also been demonstrated to have a substantial impact on Alzheimer's disease (AD). To enhance the investigation of innovative medications and give researchers a theoretical foundation, research on ApoE is required in this area. Because damage to the hippocampus is a significant concern for the population in Alzheimer's research, we need to study the effects of ApoE on the hippocampus. This paper will discuss the relationship between age and sex of hippocampal atrophy after the ApoE gene has caused AD. The paper through a method of literature review and the analysis of some clinical cases explores the impact of the ApoE gene on health, followed by a comparison of the disease state before and after, as well as the clinical pattern of hippocampal atrophy, including a description of clinical symptoms. The paper finds that ApoE significantly impacts AD and that the hippocampus is significantly atrophied after the onset of Alzheimer's disease.
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