A novel supramolecular hyperbranched polymer (SHP) is constructed through using an ABx-type amphiphilic macromonomer. The obtained SHP can form ellipsoidal unimolecular micelles and branched aggregates under different solution conditions.
Chemosensors (CSs) with dynamically tunable detection ranges have important significance for their expansion in practical applications; however, most CSs possess an unchangeable detection limit. In this work, we report the first example of a supramolecular polymer vesicle (SPV) chemosensor with a dynamically tunable detection range. SPVs containing porphyrin (PP) moieties and β-cyclodextrin (β-CD)/azobenzene (Azo) host-guest interactions were first constructed. The obtained SPVs were used to detect Zn with a high selectivity and sensitivity over a wide detection limit range of 8.67×10 to 1.99×10 under UV light irradiation. The corresponding sensing mechanism was attributed to the synergistic effects of the triple noncovalent interactions, including the metal-ligand coordination of PP/Zn and the double host-guest interactions of β-CD/Azo and β-CD/PP.
Supramolecular polymer vesicles (SPVs) with stimuli‐responsive features are promising multifunctional nanocarriers; however, improving the stability and developing multiple‐drug‐loaded SPVs remain key issues in this field. In this work, cross‐linked supramolecular hyperbranched polymer vesicles (SHPVs) with redox‐responsiveness are first constructed based on an AB2‐type macromonomer‐synthesized SHP. The obtained cross‐linked SHPVs exhibit much better size stability than those of non‐cross‐linked branched self‐assemblies, and higher double‐drug‐loading capacity compared with linear supramolecular polymer self‐assemblies. Particularly, these cross‐linked SHPVs exhibit a redox‐triggered, controlled double‐drug release behavior upon the addition of H2O2.
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