Emission spectra and excitation emission matrix of Betaine-30 (B30) dispersed in polymeric solids were determined. Emission wavelength was different for each polymer. The maximum wavelength became long with increasing the polarity of the polymer. A new possibility to determine the polarity of the medium using B30 was suggested.
An artificial metabolic route to an unnatural trichothecene was designed by taking advantage of the broad substrate specificities of the T-2 toxin biosynthetic enzymes of Fusarium sporotrichioides. By feeding 7-hydroxyisotrichodermin, a shunt pathway metabolite of F. graminearum, to a trichodiene synthase-deficient mutant of F. sporotrichioides, 7-hydroxy T-2 toxin (1) was obtained as the final metabolite. Such an approach may have future applications in the metabolic engineering of a variety of fungal secondary metabolites. The toxicity of 7-hydroxy T-2 toxin was 10 times lower than that of T-2 toxin in HL-60 cells.
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