The effect of different grades of hydroxyethyl cellulose (HEC) and hydroxypropyl methllcellulose (HPMC) on the film-formation and taste-masking ability for ibuprofen granules was evaluated. Three batches of coated ibuprofen granules were prepared using a roto-granulator, each with a different coating composition. Two grades of HEC [MW300,000 (H) and MW90,000 (L)] were combined with three different grades of HPMC [MW 11,000 (L), MW 25,000 (M) and MW 35,000 (H)] to prepare the coating solutions. Mechanical strength and physical properties of the polymer films were evaluated. Films made from HPMC (L)/HEC (H), HPMC (M)/HEC (H), and HPMC (H)/HEC (H) were stronger and more flexible than the HPMC (L) HEC (L) films. The assay, dissolution, particle size distribution, and environmental scanning electron microscopy (ESEM) data of the three batches of the coated ibuprofen granules were similar.
The preparation o f a sustained release dosage form for pseudoephedrine hydrochloride was evaluated. Beadlets (PS containing pseudoephedrine hydrochloride were prepared by spraying a slurry of pseudoephedrine hydrochloride, Eudrag t n 5-100, dibutyl sebacate and alcohol onto non-pariel seeds via the Wurster column process. The oven-dried PS beadlets were coated with different levels of Eudragitk RS (poorly water permeable) d e t e r m i n i n g t h e r e l e a s e r a t e p r o f i l e s o f t h e d r u g from t h e c o a t e d b e a d l e t s . Drug r e l e a s e from t h e c o a t e d b e a d l e t s a p p e a r e d t o f o l l o w f i r s t o r d e r k i n e t i c s . An o v e r c o a t o f E u d r a g i t n S-100 r e s i n ( 2 % c o a t i n g l e v e l ) c a n e l i m i n a t e t h e f o r m a t i o n of s o f t lumps which a r e commonly o b s e r v e d w i t h EudragitR RS c o a t e d b e a d l e t s . The EudragitH S-100 o v e r c o a t a l s o c o n t r i b u t e s t o r e t a r d d r u g r e l e a s e from t h e c o a t e d b e a d l e t s i n d i s s o l u t i o n media r a n g i n g from pH 1 . 2 t o 6 . 5 .
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