The structure of ptilomycalin A (1), a marine alkaloid possessing potent antiviral and antibiotic activites, has been determined on the basis of NMR analyses of its trifluoroacetyl (TFA) derivative (2). It has a unique structure consisting of a polycyclic guanidine and a spermidine group, each of which is linked to a 16-hydroxyhexadecanoic acid moiety. The rotational isomerism of the acylated sperimidine moiety of 2 has been studied by comparing the NMR properties of the synthetic trifluoroacetyl derivatives of spermidine (5), dipropylenetriamine (11), diethylenetriamine (12), and pentylamine (13). From these experiments, a plausible conformation of 2 and ptilomycalin A (1) has been proposed as shown in 2c, in which an anion is trapped between the guanidine and spermidine moieties. The TFA derivative 2 acts as a phase-transfer agent. NMR analysis of the stability of the complexes formed between 2 and several organic carboxylates in CDC13 solutions has been carried out.
Structure and Chemical Properties of Ptilomycalin A.-The structure of the title compound, a marine alkaloid possessing antiviral and antibiotic activities, is determined on the basis of NMR analyses of its trifluoroacetyl derivative. The latter acts as a phase-transfer agent. A NMR analysis of the stability of the complexes formed between the TFA derivative and several organic carboxylates is carried out. -(OHTANI, I.; KUSUMI, T.; KAKISAWA, H.; KASHMAN, Y.; HIRSH, S.; J. Am. Chem. Soc. 114 (1992) 22, 8472-8479; Dep. Chem., Univ. Tsukuba, Tsukuba, Ibaraki 305, Japan; EN)
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