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Background/ObjectivesVitiligo is an immune‐mediated skin disorder that targets epidermal melanocytes leading to the appearance of depigmented skin patches. Different treatment modalities have been reported with varied efficacy. We tried to evaluate the safety and efficacy of intralesional methotrexate in treating localized areas of vitiligo.MethodsThirty participants with localized patches of vitiligo were recruited. They were treated with intralesional injections of methotrexate every 2 weeks for a maximum of six sessions. At the end of the study, the degree of repigmentation was categorized into: excellent improvement (>75% repigmentation), good improvement (50%–75% repigmentation), fair improvement (25%–50% repigmentation) and poor improvement (<25% repigmentation).ResultsWe included 7 males (23.3%) and 23 females (76.7%). Their mean age was 33.6 ± 8.6 years. The duration of the disease ranged from 1 to 22 years. Four patients had a family history of vitiligo. At the end of the study, there was a highly statistically significant improvement (p < 0.001) after treatment regarding repigmentation.ConclusionsThis study showed that intralesional methotrexate is a safe and effective treatment option for patients with localized vitiligo lesions. Further studies on a larger scale are needed to evaluate the long‐term effects of treatment and detect the ideal dose to be injected.

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Urethral prolapse in children is mostly seen in prepubertal African-American girls who are usually asymptomatic on presentation and often diagnosed incidentally. We present a symptomatic urethral prolapse in a 6-year-old girl with painless vaginal bleeding. The most important point in order to avoid delayed treatment in urethral prolapse is to be aware of this rare malformation and be suspect from patients with mass and vaginal bleeding.

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