This study was carried out for the investigation of the Late Permian Wargal limestone at Kafar Kot Chashma area, Khisor Range to determine its suitability as an aggregate that is used in road construction and civil structures with the help of geological engineering testing. The results of geological engineering testing of Wargal limestone samples show the tolerable values of all standard engineering parameters including the Loss Angles Abrasion value (23.37%), Aggregate impact (16.8%), Crushing value 13.1%, Unit weight 1.67, Soundness (1.007%), Specific gravity (2.70), Water Absorption (0.48%), Flakiness Index (6.5%), Elongation value (7.1%), Coating of bitumen (> 95%), stripping of bitumen (<5%), California Bearing Ratio (CBR) value (93.6%), Maximum Dry Density 2.307g/c and Optimum Moisture Content (5.79%). As per different International and National Standards like AASHTO, ASTM, BS and NHA, the mentioned results of various engineering tests were within the tolerable limits. The petrography of the selected samples of the Late Permian Wargal limestone revealed very minor value of quartz (0.5%), hematite/limonite (0.6%) and clay content 1.0% showing the insignificant threat of ASR. The values of dolomite are limited to (1%) which shows that there is no ACR reaction with ordinary Portland cement. The results of geological and engineering parameters of the study area strongly suggest its suitability as a potential aggregate (i.e. for the base course, subbase course, cement concrete and asphalt) in the road construction.
Detailed taxonomy and biostratigraphy of the limestone, shale-rich Cretaceous Goru Formation within the western Sulaiman Range refer to diverse and well-preserved planktonic foraminifera. The age-diagnostic planktonic foraminifera encountered are;Biticinella breggiensis (middle Albian), Rotalipora ticinensis (late Albian), Rotalipora appenninica (latest Albian), Rotalipora brotzeni (early Cenomanian), Rotalipora cushmani (late Cenomanian), Whiteinella archeocretacea (latest Cenomanian-Earliest Turonian), Helvetoglobotruncana helvetica (early to middle Turonian), and Marginotruncana sigali (late middle to late Turonian). Based on the recovered planktonic foraminifera a middle Albian-late Turonian age has been assigned to the studied formation. The Rotalipora reicheli (middle Cenomanian) Zone was not identified as the First Appearance Datum of the nominal taxa present within the Rotalipora cushmani Zone. The planktonic foraminiferal assemblage characteristics suggest that the bioprovince of the Cretaceous Goru Formation belongs to the subtropical, warm water environment belonging to the Cretaceous Tethyan Realm and the palaeobiogeographic reconstruction suggests that the Neotethys was well-connected during the Albian-Turonian time interval.
Background: Multiple organ dysfunction syndrome (MODS)-specific cellular electrophysiological changes have so far not been reported and it seemed unlikely that they were related to arrhythmogenesis. Methods and Results: Twelve dogs, weight 12 ± 2 kg, were divided into a control group (n = 6) and an MODS group (n = 6). MODS lasting for 72 h was induced by the ‘two-hit’ method in 6 dogs. Ventricular myocytes were enzymatically isolated. Early afterdepolarizations (EADs), action potential duration (APD) and L-type calcium currents (ICa,L) were assessed. Sinus arrhythmias in all MODS dogs (100%; 6 of 6) and premature ventricular beats in 4 MODS dogs (66%; 4 of 6) were recorded, while no arrhythmias were found in the control animals. The prolongation of the APD was associated with a decreased ICa,L, and frequently provoked EADs were the typical electrophysiological alterations in the myocytes of MODS dogs. The action potential prolongation was shortened, the ICa,L blocked and EAD suppressed by using verapamil (100 μmol/l) in the myocytes of MODS dogs (66%; 4 of 6). Conclusion: The changes in cellular electrophysiology within 72 h in the heart of MODS dogs are APD prolongation, markedly decreased ICa,L as well as frequently provoked EAD, the most common types of arrhythmia being sinus arrhythmia and premature ventricular beats. This study suggests that verapamil appears to be an effective agent in reversing alterations in cellular electrophysiology at the early stage of MODS.
The Cretaceous pelagic carbonate succession, i.e., Goru Formation was studied in the Chutair Section, Sulaiman Range, representing part of the eastern Tethys for the paleoenvironment and bio-sequence stratigraphy. Eight planktonic foraminiferal biozones are identified which include: 1. Muricohedbergella planispira Interval Zone; 2. Ticinella primula Interval Zone; 3. Biticinella breggiensis Interval Zone; 4. Rotalipora appenninica Interval Zone; 5. Rotalipora cushmani Total Range Zone; 6. Whiteinella archeocretacea Partial Range Zone; 7. Helvetoglobotruncana helvetica Total Range Zone; and 8. Marginotruncana sigali Partial Range Zone representing Albian-Turonian age. The petrographic studies revealed five microfacies: 1. Radiolarians-rich wacke-packestone microfacies; 2. Radiolarians-rich wackestone microfacies; 3. Planktonic foraminiferal wacke-packestone microfacies; 4. Planktonic foraminiferal wackestone microfacies; and 5. Planktonic foraminiferal packestone microfacies; indicating deposition of the Goru Formation in outer-ramp to deep basinal settings. Based on the facies variations and planktonic foraminiferal biozones, the 2nd and 3rd order cycles are identified, which further include six transgressive and five regressive system tracts. The sea level curve of the Goru Formation showed fluctuation between outer-ramp and deep-basin, showing the overall transgression in the 2nd order cycle in the study area, which coincides with Global Sea Level Curve; however, the 3rd order cycle represents the local tectonic control during deposition of the strata.
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