Reentry trajectory planning has become a key issue because of the rapid development of hypersonic vehicles. In this paper, an artificial bee colony (ABC)-based direct collocation method is proposed for reentry trajectory optimization. First, the reentry trajectory optimization problem is elaborated. The principles of the ABC algorithm are then introduced. Finally, the ABC-based direct collocation method is proposed. The control variables are discretized at a set of Legendre-Gauss collocation points and are optimized with the ABC approach. The parameters in ABC are assigned in terms of both the performance and the time cost of the algorithm. A penalty factor is adopted to modify the fitness value of some particular individuals in the colony so that every individual can be fully used. Series of comparative experimental results verify the feasibility and effectiveness of our proposed method. Further discussions and simulations are given for analyzing the impact of ABC parameters on the performance of the method.
Objectives. To study effects of 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) on RANKL signaling pathway and pathway-associated cytokines in patients with rheumatoid arthritis (RA). Methods. Receptor activator of nuclear factor-kappa B ligand (RANKL), osteoprotegerin (OPG), IFN-γ, IL-6, TNF-α, IL-17, and IL-4 were examined in 54 patients with incipient RA using a cytometric bead array (CBA) or an enzyme-linked immunosorbent assay (ELISA). Results. After 72 hours of incubation of peripheral blood mononuclear cells (PBMCs) with 1,25(OH)2D3 in RA patients, the levels of RANKL, TNF-α, IL-17 and IL-6 significantly decreased compared to those of the control. 1,25(OH)2D3 had no significantly impact on the levels of OPG, RANKL/OPG, and IL-4. Conclusions. The present study demonstrated that 1,25(OH)2D3 reduced the production of RANKL and the secretion of TNF-α, IL-17, and IL-6 in PBMCs of RA patients, which indicated that 1,25(OH)2D3 might be able to decrease damage of cartilage and bone in RA patients by regulating the expression of RANKL signaling pathway and pathway-associated cytokines.
The effects of forest restoration on ecosystem services and their trade-offs are increasingly discussed by environmental managers and ecologists, but few demonstrations have analyzed ecosystem service trade-offs with a view to informing afforestation choices. Here, we examined how the Grain for Green Program (GGP), an ambitious reforestation program in China, affected ecosystem services. We quantified regulating services and provisioning service in the potential scenarios, which were developed to improve ecosystem services better. The results indicated the GGP drove 14.5% of land-use/land-cover from 2000 to 2015, and all the regulating services increased. Prioritizing reforestations in steep-sloped and riparian farmlands can promote flood mitigation, water purification, and soil retention services by 62.7%, 25.5%, and 216.1% as compared with 2015 levels, respectively, suggesting that the improvements strongly depend on afforestation locations. Driven by the new GGP policy, a high proportion of economic forest increased provisioning service (272.2%), but at the expense of decreases in soil retention (−25.1%), flood mitigation (−11.4%), water purification (−36.6%), and carbon storage (−48.5%). We identified a suitable scenario that would reduce the trade-offs, which associated with afforestation types and their spatial allocation. Identifying priority areas of afforestation types can inform the GGP policy to assure sustainable and broader benefits.
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