Monoubiquitination of histone H2B on lysine 120 (H2Bub1) is an epigenetic mark generally associated with transcriptional activation, yet the global functions of H2Bub1 remain poorly understood. Ferroptosis is a form of non‐apoptotic cell death characterized by the iron‐dependent overproduction of lipid hydroperoxides, which can be inhibited by the antioxidant activity of the solute carrier family member 11 (SLC7A11/xCT), a component of the cystine/glutamate antiporter. Whether nuclear events participate in the regulation of ferroptosis is largely unknown. Here, we show that the levels of H2Bub1 are decreased during erastin‐induced ferroptosis and that loss of H2Bub1 increases the cellular sensitivity to ferroptosis. H2Bub1 epigenetically activates the expression of SLC7A11. Additionally, we show that the tumor suppressor p53 negatively regulates H2Bub1 levels independently of p53's transcription factor activity by promoting the nuclear translocation of the deubiquitinase USP7. Moreover, our studies reveal that p53 decreases H2Bub1 occupancy on the SLC7A11 gene regulatory region and represses the expression of SLC7A11 during erastin treatment. These data not only suggest a noncanonical role of p53 in chromatin regulation but also link p53 to ferroptosis via an H2Bub1‐mediated epigenetic pathway. Overall, our work uncovers a previously unappreciated epigenetic mechanism for the regulation of ferroptosis.
Stability and Hopf bifurcation of a nonlinear electromechanical coupling system with time delay feedback * Liu Shuang(刘 爽) a)b) , Zhao Shuang-Shuang(赵双双) a) , Wang Zhao-Long(王兆龙) a) , and Li Hai-Bin(李海滨) a)b) † a)
With the rapid progress of urbanization, the loss of cultivated land has attracted great attention worldwide, and economic compensation is one of the incentives commonly used by the governments to enhance farmers’ enthusiasm in protecting cultivated land. In recent years, although various economic compensation modes have been implemented by the Chinese government, such modes are still experimental and exploratory. Thus, designing and implementing a national economic compensation mode is urgent to effectively protect the quantity and quality of cultivated land. This study focuses on the mode of cultivated land protection fund (CLPF) in Chengdu, which is the earliest mode of the implementation of economic compensation in China in 2008. First, we analyzed the farmers’ satisfaction with the CLPF through a face-to-face interview with 296 farmers in Chengdu. Then, we used the path analysis method to identify the influencing factors of farmers’ satisfaction from the characteristics of farmers and the policy. Results show that the CLPF was generally supported by farmers. Nevertheless, room for improvement still exists. Particularly, farmers’ satisfaction was low in the design of the government’s supervision management of the CLPF. Farmers’ satisfaction with compensation standard, funding use requirement, and the government’s supervision management were remarkably affected by factors, including farmers’ educational level, cultivated land area, total annual agricultural income, farmers’ knowledge of the CLPF, farmers’ recognition of the value of the CLPF, and farmers’ perception of the changes in household economics. Particularly, the direct influence of farmers’ perception of the changes in household economics was the most important. Finally, we proposed the recommendations for constructing a national economic compensation mode for cultivated land protection. Our results have certain guiding significance for promoting the sustainable development of cultivated land protection policies by means of economic incentives in China and other countries.
The significant spatial heterogeneity among river basin ecosystems makes it difficult for local governments to carry out comprehensive governance for different river basins in a special administrative region spanning multi-river basins. However, there are few studies on the construction of a comprehensive governance mechanism for multi-river basins at the provincial level. To fill this gap, this paper took Henan Province of China, which straddles four river basins, as the study region. The chord diagram, overlay analysis, and carbon emission models were applied to the remote sensing data of land use to analyze the temporal and spatial patterns of carbon storage caused by land-use changes in Henan Province from 1990 to 2018 to reflect the heterogeneity of the contribution of the four basins to human activities and economic development. The results revealed that food security land in the four basins decreased, while production and living land increased. Ecological conservation land was increased over time in the Yangtze River Basin. In addition, the conversion from food security land to production and living land was the common characteristic for the four basins. Carbon emission in Henan increased from 134.46 million tons in 1990 to 553.58 million tons in 2018, while its carbon absorption was relatively stable (1.67–1.69 million tons between 1990 and 2018). The carbon emitted in the Huai River Basin was the main contributor to Henan Province’s total carbon emission. The carbon absorption in Yellow River Basin and Yangtze River Basin had an obvious spatial agglomeration effect. Finally, considering the current need of land spatial planning in China and the goal of carbon neutrality by 2060 set by the Chinese government, we suggested that carbon sequestration capacity should be further strengthened in Yellow River Basin and Yangtze River Basin based on their respective ecological resource advantages. For future development in Hai River Basin and Huai River Basin, coordinating the spatial allocation of urban scale and urban green space to build an ecological city is a key direction to embark upon.
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