Identification of pulmonary ground-glass opacity (GGO) lesions during bronchoscopic procedures remains challenging, as GGOs cannot be directly visualized under 2-dimensional (2D) fluoroscopy and are often difficult to detect by radial endobronchial ultrasound. Recently, a mobile 2D/3D C-arm fluoroscopy system was developed that provides both 2D fluoroscopy and mobile 3D imaging to assess and confirm the location of the lesions and ancillary bronchoscopic tools. However, previous studies focused mainly on experience of utilizing mobile 3D C-arm system for transbronchial biopsy of solid pulmonary nodules. Here, we evaluated the feasibility of mobile 3D imaging assisted transbronchial biopsy with and without ablation of two patients with GGO nodules. The first patient underwent biopsy only, and the second patient underwent biopsy in the right upper lobe lung nodule and ablation of a left upper lobe lung nodule in one session. Procedures in both patients were successfully performed, and no significant complications have been observed intra-or post-procedurally. Our case study highlights the potential value of the mobile 3D imaging system in accurate identification of the target lung lesion, confirmation of bronchoscopic tools within the lesion, and assessment of the target lesion and surrounding tissue following bronchoscopic ablation procedure. Furthermore, a "one-stop shop" bronchoscopy workflow combining both biopsy and ablation for one or more lung lesions in one session could be made possible by utilizing a hybrid mobile 2D/3D C-arm system in the bronchoscopy suite.
Metastability-engineering, e.g., transformation-induced plasticity (TRIP), can enhance the ductility of alloys, however it often comes at the expense of relatively low yield strength. Here, using a metastable Ti-1Al-8.5Mo-2.8Cr-2.7Zr (wt.%) alloy as a model material, we fabricate a heterogeneous laminated structure decorated by multiple-morphological α-nanoprecipitates. The hard α nanoprecipitate in our alloy acts not only as a strengthener to the material, but also as a local stress raiser to activate TRIP in the soft matrix for great uniform elongation and as a promoter to trigger interfacial delamination toughening for superior fracture resistance. By elaborately manipulating the activation sequence of lamellar-thickness-dependent deformation mechanisms in Ti-1Al-8.5Mo-2.8Cr-2.7Zr alloys, the yield strength of the present submicron-laminated alloy is twice that of equiaxed-coarse grained alloys with the same composition, yet without sacrificing the large uniform elongation. The desired mechanical properties enabled by this strategy combining the laminated metastable structure and trifunctional nanoprecipitates provide new insights into designing ultra-strong and ductile materials with great toughness.
Abstract. In order to research the hot deformation behaviors of Cu/Al laminated composites, isothermal hot compression tests were conducted on a Gleeble-1500D thermo-mechanical simulator in the temperature range of 300 ~ 450°C and strain rate range of 0.01 ~ 1 s -1 . After hot compression, the cooperative deformation behaviors between Cu and Al were discussed. The effects of deformation temperature and strain rate on the deformation behaviors were described using an Arrhenius-type constitutive equation. Furthermore, considering the effect of strain, the constitutive model was modified. The predicated flow stress values obtained from the modified constitutive equation could be well in accord with the experimental values. High correlation coefficient and low average absolute relative error demonstrate the high accuracy of the constitutive model developed in this work.
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