To study the mechanism of vault lining under different void heights and verify the strengthening effect of the attached steel plate, a CDP (concrete-damaged plasticity) model and the XFEM (extended finite element method) were used to construct the local numerical model of the vault void, and an experiment was carried out for verification. The strengthened structure of the steel plate was assembled with a combination of a two-component epoxy adhesive and chemical anchor bolts. Five lining models with various void thicknesses, together with their strengthened models, were evaluated. The results of the established numerical model were compared with the experimental results in terms of failure mode, vertical displacement, and load-deformation results. The results of the two numerical models were in good agreement with the experimental results, revealing the failure mechanism of the vault lining. The rigidity of the specimen after steel plate strengthening was significantly improved. When the void height was one-fourth of the secondary lining thickness, the lining cracks were reduced from 14 to 4, and the distribution width of the cracks was also reduced from 1.047 to 0.091 m after steel plate strengthening. The level of damage caused by cracking was significantly reduced, which proves the effectiveness of the surface-sticking method for steel plate strengthening.
Loess tunnels often undergo large-scale deformation with complex spatial and temporal distribution. Mastering the characteristics of spatial and temporal deformation is conducive to precise policy implementation and the control of large deformation of the tunnel. In this study, relying on the Yulinzi Tunnel in Gansu Province, China, based on 3D laser scanning technology, the tunnel was monitored for a short period of 24 h and a long period of 36 days. The refined characteristics of the temporal and spatial deformation of the representative points of the interrupted surface, the tunnel face, and the excavation mileage during the excavation process of the three-bench and seven-step method of the tunnel were analyzed. The results show that the tunnel’s arch has large deformation, and there is twisting deformation. The distribution of the overall deformation of the tunnel is related to the excavation sequence, showing a stepped deformation law. With the construction of the following excavation process, the deformation rate of the tunnel always indicates the characteristics of significant in the early stage and small in the later stage, and the overall deformation changes with time in accordance with the distribution law of the exponential function. The research results provide a reference for predicting the deformation development trend of loess tunnels and providing reasonable deformation control methods.
The present work has been performed to evaluate the effect of three shaped holes (cylindrical hole, expansion-shaped hole and fan-shaped hole) with forward injection and backward injection on film cooling effectiveness on the adiabatic wall flat plate. All the cases are computed under eight blowing ratios (M) = [0.25, 0.5, 0.75, 1.0, 1.25, 1.5, 1.75 and 2.0]. The results show that for film cooling hole structure with backward injection, a pair of rotating vortex is formed at the outlet of film cooling hole. Differing from the classical counter rotating vortex pair (CRVP) found in each hole with forward injection, the vortexes are expanded away from the test wall under the function of transverse main flow and are broken quickly. It indicates that the rotating vortex pair does not promote the mixing of main flow and jet flow. The uniformity of local film cooling effectiveness of the hole with backward injection is higher than that of the hole with forward injection. In terms of the spatially averaged film cooling effectiveness with a certain hole shape, the value under backward injection exceeds that under forward injection at a certain point: (1) M=0.5 for cylindrical hole, (2) M=0.75 for expansion-shaped hole and (3) M=1.25 for fan-shaped hole. The comparison of the calculation results of different holes with backward injection shows that in the case of high blowing ratio, a uniform distribution with higher film cooling effectiveness is easier to achieve with fan-shaped hole.
Background: Congenital myasthenic syndromes (CMS) refer to a series of inherited disorders caused by defects in various proteins. Mutation in the collagen-like tail subunit of asymmetric acetylcholinesterase (COLQ) is the second-most common cause of CMS. However, data on pharmacological treatments are limited. Objective: In this study, we reviewed related reports to determine the most appropriate pharmacological strategy for CMS caused by COLQ mutations. A literature review and meta-analysis were also performed. PubMed, MEDLINE, Web of Science, and Cochrane Library databases were searched to identify studies published in English before July 22, 2022. Results: A total of 42 studies including 164 patients with CMS due to 72 different COLQ mutations were selected for evaluation. Most studies were case reports, and none were randomized clinical trials. Our meta-analysis revealed evidence that β- adrenergic agonists, including salbutamol and ephedrine, can be used as first-line pharmacological treatments for CMS patients with COLQ mutations, as 98.7% of patients (74/75) treated with β-adrenergic agonists showed positive effects. In addition, AChEIs should be avoided in CMS patients with COLQ mutations, as 90.5% (105/116) of patients treated with AChEIs showed no or negative effects. Conclusion: (1) β-adrenergic agonist therapy is the first pharmacological strategy for treating CMS with COLQ mutations. (2) AChEIs should be avoided in patients with CMS with COLQ mutations.
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