Malignant cancers employ diverse and intricate immune evasion strategies, which lead to inadequately effective responses of many clinical cancer therapies. However, emerging data suggest that activation of the tolerant innate immune system in cancer patients is able, at least partially, to counteract tumor-induced immunosuppression, which indicates triggering of the innate immune response as a novel immunotherapeutic strategy may result in improved therapeutic outcomes for cancer patients. The promising innate immune targets include Toll-like Receptors (TLRs), RIG-I-like Receptors (RLRs), and Stimulator of Interferon Genes (STING). This review discusses the antitumor properties of TLRs, RLRs, and STING-mediated innate immune pathways, as well as the promising innate immune targets for potential application in cancer immunotherapy.
A series of repeated load triaxial tests were conducted in this study to investigate the influences of compaction density and postcompaction moisture variation on the dynamic elastic modulus (Ed) and plastic permanent strain (PPS) of compacted lateritic soil. Specimens were compacted at optimum moisture content (OMC) and three degrees of compaction (90%, 93%, and 96%). Then the specimens were dried or wetted to different moisture contents (OMC,OMC±3%,OMC±6%, andOMC+9%) prior to testing forEdand PPS. Results show that moisture content has greater influence on theEdand PSS than compaction degree, and the increase in moisture content leads to a decrease ofEdand an increase of PPS. Furthermore, an empirical relationship betweenEdand applied cyclic stress (σd) is developed that incorporates density and moisture variations. Three different evolution types of PPS with number of load cycles, plastic stable, plastic creep, and incremental collapse, are identified as the increase of moisture content. In addition, the critical dynamic stress (σdc) separating stable and unstable deformation is determined based on the shakedown concept. The envelope curves ofσdc-moisture of lateritic soil with different degrees of compaction are also determined to provide reference for the pavement design.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.