BackgroundLaboratory studies have demonstrated statin-induced apoptosis of cancer cells, including breast cancer cells, and evidence is accumulating on the mechanism of statin-induced apoptosis. However, despite numerous epidemiological studies, no consensus has been reached regarding the relationship between statin use and breast cancer risk.MethodsThis retrospective case–control study enrolled 4332 breast cancer patients and 21,660 age-matched controls registered in the National Health Insurance program of Taiwan, which covers approximately 99% of the population. The study cases were women for whom a diagnosis of breast cancer (ICD-9-CM code 174.X) had been recorded in LHID2005 between January 1, 2004 and December 31, 2010. A logistic regression model was adjusted for potential confounding factors, including the level of urbanization, and the Charlson Comorbidity Index was applied to assess potential comorbidities. We also considered possible bias caused by random urbanization, because nutrition and lifestyle factors are related to breast cancer incidence.ResultsOur results showed that lovastatin was associated with a lower risk of breast cancer (adjusted OR 0.596; 95% CI 0.497–0.714; p < 0.001), and atorvastatin exhibited a protective tendency against breast cancer (adjusted OR 0.887; 95% CI 0.776–1.013; p < 0.077).ConclusionsAlthough no consensus has been established regarding the relationship between statin use and breast cancer risk, our study indicated that lovastatin is a potential chemopreventive agent against breast cancer. Further detailed research is warranted.
Objectives The aim of this study is to explore the effects of exercise on the relationship between job stress and the components of metabolic syndrome. Methods A 12-week long worksite exercise program was developed for banking and insurance enterprises with a total of 89 workers participating in it. Participants were divided into three (low, medium and high) levels of exercise intervention subgroups. All were asked to complete a structured questionnaire which contained demographic and lifestyle data, SF-36, and measurements for job stress pre-and post-intervention. The profi les of metabolic syndrome (BMI, waist circumference, fasting blood glucose, triglyceride, and high-density lipoprotein cholesterol) were also measured before and after the intervention. Results The scores of individual fatigue (an indicator of job strain reaction) were signifi cantly improved in medium and high intervention groups, and notable improvements (p<0.05) in waist circumference and systolic blood pressure were found only in high intervention group. Higher exercise intervention was signifi cantly related to greater reductions in waist circumference, systolic blood pressure, individual fatigue, and work fatigue, with adjustment for the covariant variables of job demand, job control, sex, age, smoking status, and regular daily food intake. Conclusions This study demonstrated an effective approach to worksite exercise intervention in banking and insurance enterprises. The present results show a triangular connection between job stress, metabolic syndrome and physical activity. on 1 May 2019 by guest. Protected by copyright.
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