Background:Hepatitis C virus has infected 130 to 150 million individuals globally. Atypical chemokine receptor 1 has become a focus of research because of its diverse roles in different diseases. However, little is known regarding the association of atypical chemokine receptor 1 polymorphism with susceptibility to hepatitis C virus.Aims: To determine the association of an atypical chemokine receptor 1 polymorphism (rs12075) with hepatitis C virus susceptibility.Study Design: Case-control study.Methods: We collected blood samples from 231 patients infected with hepatitis C virus and 239 blood donors as control subjects. Genotyping of atypical chemokine receptor 1 was performed using a 5ˊ-nuclease assay with TaqMan-minor groove binding probes. Comparisons between hepatitis C virus-infected patients and control subjects were assessed using Fisher’s exact test.Results: The genotype frequencies of FY*A/FY*A, FY*A/FY*B and FY*B/FY*B were 86.1%, 13.9% and 0% in the patient group, and 86.2%, 13.4% and 0.4% in the control group, respectively. The difference in atypical chemokine receptor 1 genotype frequencies between hepatitis C virus-infected patients and control group was not significant (p=1.00, OR=1.004, 95% CI=0.594-1.695). FY*A and FY*B allele frequencies were 93.1% and 6.9% in the patient group, and 92.9% and 7.1% in the control group, respectively. The difference in atypical chemokine receptor 1 allele frequencies between hepatitis C virus-infected patients and the control group was not significant (p=1.00, OR=0.972, 95% CI=0.589-1.603).Conclusion: Our result indicates that atypical chemokine receptor 1 polymorphism (rs12075) does not affect susceptibility to hepatitis C virus.
Applying electroosmosis to sludge dewatering practically, methods for improving electroosmotic dewatering must be explored. The influence of initial pH, adding Al2 (SO4)3 dose and ash content in sludge on electroosmotic dewatering behavior was investigated. The results show that acid or alkaline environment is unfavorable for electroosmotic dewatering, especially initial pH of sludge closing to the isoelectric point, electroosmotic dewatering behaves worst. With increasing Al2(SO4)3 coagulant-aid dose, the decreasing rate of water content becomes slower gradually during electroosmotic dewatering. Besides, higher ash content in sludge has a better effect on vaccum filtration, but slightly impact on electroosmotic dewatering. When ash content increases to 69.9% from 52.4%, final water content reduces to 64.3% from 78.3% using vaccum filtration, and the decreasing amount of water content by electroosmotic dewatering ranges from 16.5% to 12.3%.
According to the characteristics of the design process of top-down collaborative
assembly design, process planning dynamic model based on HOOPN (hierarchical object-oriented
Petri-net) is constructed for top-down collaborative assembly design. The outside and inside task
dependent relationships among the task groups include parallel, sequence and coupling are
implemented. The definitions of attribute for each element and the activation rules are presented for
Petri-net. The fuzzy overall evaluation model is applied for risk evaluation of design process, and
the local and global risk level is determined. The whole process planning is adjusted and controlled
based on special risk decision-making mechanism.
Powerline interference (PLI) often exhibits variations in frequency and amplitude, whose frequency lies in the spectrum range of the ECG signal. Most previous attempts of tracking time-varying PLI signal are based on Least Squared (LS) algorithm. This makes their methods susceptible to QRS complex in tracking low-level PLI signal. This study presents a new robust Kalman filter-based PLI suppressor to overcome the limitation of existing methods. M-estimation is incorporated into the kalman filter to combat the adverse effect of QRS impulsive. Simulation results indicate that our method outperforms the former LS-based PLI cancellers in both suppressing interference and preserving meaningful ECG components at various interference levels.
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