A Rh -catalyzed intramolecular oxidative cross-coupling between double bonds for the synthesis of macrolides is described. Under the optimized reaction conditions, macrocycles containing a diene moiety can be formed in reasonable yields and with excellent chemo- and stereoselectivity. This method provides an efficient approach to synthesize macrocyclic compounds containing a 1,3-conjugated diene structure.
AR h III -catalyzed intramolecular oxidative crosscoupling between double bonds for the synthesis of macrolides is described. Under the optimizedreaction conditions,macrocycles containing ad iene moiety can be formed in reasonable yields and with excellent chemo-and stereoselectivity.T his method provides an efficient approach to synthesize macrocyclic compounds containing a1,3-conjugated diene structure.Scheme 1. Synthesis of macrocyclic compounds containing a1,3-conjugated diene moiety.
A palladium-catalyzed dialkylation
of 1,3-dien-5-ynes was developed
using alkenyl double bonds as the initiator and terminator for the
synthesis of functionalized indene derivatives. The reactions were
performed under mild reaction conditions, affording the corresponding
multi-substituted indene derivatives in high efficiency via unprecedented
5-endo cyclization and alkylation processes. It was
found that the substituent location at the alkenyl double bond was
essential for the chemoselective synthesis of the indene and naphthalene
derivatives, respectively.
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