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A particularly interesting discovery in observations of GRB 121027A is that of a giant X-ray bump detected by the Swift/XRT. The X-ray afterglow re-brightens sharply at ∼ 10 3 s after the trigger by more than two orders of magnitude in less than 200 s. This X-ray bump lasts for more than 10 4 s. It is quite different from typical X-ray flares. In this letter we propose a fall-back accretion model to interpret this X-ray bump within the context of the collapse of a massive star for a long duration gamma-ray burst. The required fall-back radius ∼ 3.5 × 10 10 cm and mass ∼ 0.9 − 2.6 M ⊙ imply that a significant part of the helium envelope should survive through the mass loss during the last stage of the massive progenitor of GRB 121027A.

Techniques for test-case prioritization re-order test cases to increase their rate of fault detection. When there is a fixed time budget that does not allow the execution of all the test cases, time-aware techniques for test-case prioritization may achieve a better rate of fault detection than traditional techniques for test-case prioritization. In this paper, we propose a novel approach to time-aware test-case prioritization using integer linear programming. To evaluate our approach, we performed experiments on two subject programs involving four techniques for our approach, two techniques for an approach to time-aware test-case prioritization based on genetic algorithms, and four traditional techniques for testcase prioritization. The empirical results indicate that two of our techniques outperform all the other techniques for the two subjects under the scenarios of both general and version-specific prioritization. The empirical results also indicate that some traditional techniques with lower analysis time cost for test-case prioritization may still perform competitively when the time budget is not quite tight.

We recommend that the nurse-to-patient ratio on medical and surgical units in Chinese hospitals be increased to at least 0.5-0.6 so as to secure patient safety and the quality of health services.

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Humoral immunity against diverse pathogens is rapidly elicited from natural antibody repertoires of limited complexity. But the organizing principles underlying the antibody repertoires that facilitate this immunity are not well-understood. We used HER2 as a model immunogen and reverse-engineered murine antibody response through constructing an artificial antibody library encoded with rudimentary sequence and structural characteristics learned from high throughput sequencing of antibody variable domains. Antibodies selected in vitro from the phage-displayed synthetic antibody library bound to the model immunogen with high affinity and specificities, which reproduced the specificities of natural antibody responses. We conclude that natural antibody structural repertoires are shaped to allow functional antibodies to be encoded efficiently, within the complexity limit of an individual antibody repertoire, to bind to diverse protein antigens with high specificity and affinity. Phage-displayed synthetic antibody libraries, in conjunction with high-throughput sequencing, can thus be designed to replicate natural antibody responses and to generate novel antibodies against diverse antigens.

Kodamaea (Pichia) ohmeri was formerly considered a contaminant, but is now known to be a significant human pathogen that has been shown to cause fungemia, endocarditis, funguria, and peritonitis in immunocompromised patients. We report a case of fungemia caused by K. ohmeri in a 71-year-old man with cellulitis. The patient was sent to the emergency room due to leg edema, fever, and change of consciousness. During hospitalization, a series of examinations including blood cultures were performed. On hospital day 8, blood culture yielded a yeast colony. Fluconazole was given empirically, but had no effect. The pathogen was identified as K. ohmeri by Vitek YBC card, API 20C, sequencing of the 18S rRNA gene, and the D1/D2 domains of the 26S rRNA gene and the internally transcribed spacer (ITS) regions. Antifungal susceptibility testing was performed with the ATB-Fungus system, and a high minimum inhibitory concentration (level up to 64 mg/l) for fluconazole was found. Fluconazole was replaced with amphotericin B deoxylate, and the fever and cellulitis inflammation gradually subsided. The patient was discharged in a stable condition. This is the first case of K. ohmeri fungemia in Taiwan.