Background: The prediction of conformational B-cell epitopes is one of the most important goals in immunoinformatics. The solution to this problem, even if approximate, would help in designing experiments to precisely map the residues of interaction between an antigen and an antibody. Consequently, this area of research has received considerable attention from immunologists, structural biologists and computational biologists. Phage-displayed random peptide libraries are powerful tools used to obtain mimotopes that are selected by binding to a given monoclonal antibody (mAb) in a similar way to the native epitope. These mimotopes can be considered as functional epitope mimics. Mimotope analysis based methods can predict not only linear but also conformational epitopes and this has been the focus of much research in recent years. Though some algorithms based on mimotope analysis have been proposed, the precise localization of the interaction site mimicked by the mimotopes is still a challenging task.
We present a facile synthesis of manganese oxide (MnO(2)) nanocomposite with ultraviolet (UV) photosensitive characteristic by a solid-state reaction based on the reduction of potassium permanganate (KMnO(4)) by aniline, which provides a new family and more selectivity for UV photosensitive nanomaterials in the future.
A promising nitrite sensor based on one-dimensional polyoxometalate hybrid nanofibers was prepared and developed by electrospinning of a mixture of poly(vinyl alcohol) and a-K 6 [P 2 W 18 O 62 ]·14H 2 O (P 2 W 18 ) onto the surface of an indium tin oxide (ITO) electrode. After thermal crosslinking, the P 2 W 18 hybrid nanofibers are insoluble in aqueous solutions even after a period of 24 hours, which ensures the electrochemical stability of the P 2 W 18 hybrid nanofiber-modified ITO electrode. The cyclic voltammetry results have demonstrated that the P 2 W 18 hybrid nanofibermodified ITO electrode exhibits excellent electrocatalytic activity toward the reduction of nitrite in acidic solutions. Additionally, long-term stability and reproducibility have been observed.
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