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We studied the prognostic applicability of electroencephalograms (EEGs) of seventy-nine patients within 24 hours after successful cardiopulmonary resuscitation. The EEGswere classified into five grades according to a modified Hockaday's scale. The EEGs of grades I and II implied full recovery, while those of grade III gave a varied but generally unfavorable prognosis. Patients with grades IV and V EEGssurvived in a vegetative condition or died without awakening. Eighteen patients showed EEGwith periodic patterns, all of which led to a fatal or vegetative outcome. One case showed EEGs associated with periodic triphasic waves and repetitive sharp transients in the same record. Several cases showed EEGswith different periodic patterns in consecutive records.Weconclude that an EEGis a good indicator of patient prognosis after cardiopulmonary resuscitation. However, the clinical significance of morphological differences of various periodic patterns that can occur during an EEGremains to be established. (Internal Medicine 34: 71-76, 1995)

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Association of the syndrome of inappropriate secretion of antidiuretic hormone (SIADH)with multiple sclerosis (MG) is very rare, although many other disorder of the nervous system have been reported to be associated with this syndrome; there is only one case report in the literature. Wedescribe here a patient with the syndrome associated with MS.A 62-year-old womanhad a variety of neurologic symptoms,where clinical course was typical of MS.Transient episodes of hyponatremia and disturbance of consciousness occurred repeatedly with deterioration of MS. The concentration of antidiuretic hormone (ADH)was high whereas the plasma osmolality was low in the presence of concentrated urine, during the episodes of hyponatremia. Urinary Na excretions exceeded 20 mEq/day. Computed tomography and magnetic resonance imaging revealed lesions in the brain, especially in the periventricular region. The hypothalamus and pituitary appeared normal by these imaging methods. Since the periventricular region surrounds and may be functionally connected to the hypothalamus which plays the central role in the regulation of ADHsecretion, it was concluded that association of SIADHand MSin this patient was not coincidental, and that demyelinating processes in the periventricular region exerted an abnormal influence on ADH secretion resulting in SIADH. Contribution of other mechanisms as increased intrathoracic pressure, however, could not be excluded completely.

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Rabbit milk fat globule membranes have been shown to contain PRL receptors by a variety of criteria, including hormonal specificity and inhibition by specific anti-PRL receptor antisera. Collection of milk samples throughout the period of lactation facilitated a temporal study of the receptor content of the membrane fraction of these milk samples by Scatchard analysis after treatment with 5 M MgCl2 to dissociate endogenously bound PRL. Total receptor content was low after parturition (3.3 +/- 1.3 fmol/mg membrane protein) but increased subsequently, reaching maximal levels (43.7 +/- 3.4 fmol/mg) by day 21 of lactation. No significant difference in the Ka (4.9 X 10(9) +/- 0.35 M-1) of the milk receptor was detected over a 4-week suckling period. No apparent relation seemed to exist between rabbit serum PRL values measured by RIA in serum samples taken just before milking and milk PRL receptor content. Milk receptor content, however, was significantly (P < 0.02) correlated with the PRL receptor content of the gland when animals were sacrificed immediately after milking.

Changes in concentrations of arginine vasopressin (AVP) in plasma and the neurointermediate lobe of the pituitary and those in dopamine (DA) in the neurointermediate lobe in rats were studied simultaneously after depriving the animals of water as well as after giving intraperitoneal (i.p.) injections of hypertonic saline (4.5% saline, 25 ml/kg of body weight). After water deprivation for 24 h, both AVP in plasma and DA in the neurointermediate lobe increased without any changes in AVP in the neurointermediate lobe. Water deprivation for 48-72 h caused further increases in both AVP in plasma and DA in the neurointermediate lobe with a significant decrease in AVP in the neurointermediate lobe. Rehydration for 24 h subsequent to 72 h of water deprivation made AVP in plasma and DA in the neurointermediate lobe return to the values of normally hydrated rats, whereas AVP in the neurointermediate lobe was still depressed. Thirty min after the i.p. injection of hypertonic saline, both AVP in plasma and DA in the neurointermediate lobe increased markedly with no change in AVP in the neurointermediate lobe. The time course of change in DA in the neurointermediate lobe was similar to that in plasma AVP when plasma osmolality was changed chronically or acutely. These results may make questionable the preconception that the tuberohypophyseal DA neurons are not involved in or regulated by early changes in vasopressin secretion.