Aim: The study aims to investigate the antimicrobial activity of herbal extracts from Tabuk region against nosocomial pathogens.
Material and Methods:The plants included in this study were collected according to United States Department of Agriculture (USDA). The plants were grinded into fine powder using electric grinder, and the powder was transferred into air tight containers. Extracts of this powder was prepared in form of stock solution that was further used for preparing solutions of different concentrations. Antibacterial tests including minimum inhibitory concentration and maximum bactericidal concentration, broth dilution method, and well-diffusion method were performed.
Results:The current study has determined the herbs that possess antimicrobial activity against the most common nosocomial pathogens. The sample extracts including Achinella fragrantissima, Artemisia judaica, Caralluma quadrangular, Cleome droserifera, Rhyza stricta, Moringa, and Ochradenus baccatus were tested for organisms including; Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, and Candida albicans. The results have depicted positive anti-microbial activity of herbal shrubs.
Conclusion:The results have demonstrated positive and promising anti-microbial activities against the nosocomial pathogens.
Chemoprevention with alternative approaches is emerging as a significant component of therapeutic regimen for the management of various diseases in human population including cancer. The concept of personalized nutrition is attracting considerable interest as an effective and affordable strategy in the prevention of chronic diseases. It is acknowledged that diet-derived agents or non-dietary natural products are not only the source of traditional medicines but also the lead compounds for currently used pharmaceuticals with excellent efficacy against a number of human diseases. Achillea species (Asteraceae) are considered as functional foods, which are important constituents of traditional medicine and commonly consumed as herbal tea or food additives worldwide. The studies presented herein demonstrate the effects of the hydro-methanolic extract of A. fragrantissima against a panel of cancer cells that include breast cancer (MDA-MB-231,MCF-7,SKBR3), pancreatic cancer (BxPC-3, MiaPaCa-2), prostate cancer (LNCaP,C4-2B,PC-3), and lung cancer (A549). The experimental results presented in the study show that the extract, which is rich in structurally diverse phytochemicals, effectively inhibits the cell growth and induces apoptotic cell death in human cancer cells. The treatment of the cancer cells with the extract resulted in a progressive decrease in cell migration and invasiveness, demonstrating an effective anti-metastatic activity. The mechanism by which the extract exerts its effects against cancer cells potentially engages NF-κB signaling and downregulation of its target cytokines such as VEGF. The study provides evidence that partially support the importance of functional foods and highlights their significance in disease prevention.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.