In this article a model based on cellular automata (CA) is proposed to simulate the degradation for biodegradable polymer. The transformational rule of this model is constructed based on the hydrolysis reaction, oligomer diffusion equations and the relationship between intensity and number average molecular weight of the polymer. Furthermore, polymer DLPLA plate corresponding to this CA model was carried out. The simulation shows the middle hollow result which is accordance with the experiment phenomenon. The molecular in the degradation process has good fit with the experiment data. It proves that the model in this article is right and can provide numerical lead for the designs of biodegradable polymer devices.
Although the degradation modeling of tissue engineering scaffold is in its initial step, it can direct the design, optimization of scaffold and help the application in medical case of illness. This paper analyzes the modeling methods and gives the speciality of every model which is put forward by researchers in China and abroad about the degradation of tissue engineering scaffold. These models are divided into micro scale, macro scale and two scale models based on the modeling scales. The recent research is belonging to single scale modeling. Some researchers abroad probed to two scale modeling. The future model is prospected in multi scale coupling macro, micro, and meta-macro model.
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