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Bacillus pumilus BN-103 was found to produce a newantibiotic complexnamedamicoumacin. The antibiotic was isolated from the culture broth by ion-exchange resin and carbon chromatographies. AmicoumacinA was a major componentof the mixture, and exhibited not only antibacterial activity, but also antiinflammatory and antiulcer activities. AmicoumacinB and C showed moderate activity against bacteria, but did not exhibit any pharmacological activity.

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