Purpose: We performed a phase I trial to investigate the safety, clinical responses, and Wilms' tumor 1 (WT1)-specific immune responses following treatment with dendritic cells (DC) pulsed with a mixture of three types of WT1 peptides, including both MHC class I and II-restricted epitopes, in combination with chemotherapy.
Using deep Chandra ACIS observation data for Cygnus A, we report evidence of non-thermal Xray emission from radio lobes surrounded by a rich intra-cluster medium (ICM). The diffuse X-ray emission, which are associated with the eastern and western radio lobes, were observed in a 0.7-7 keV Chandra ACIS image. The lobe spectra are reproduced with not only a single-temperature Mekal model, such as that of the surrounding ICM component, but also an additional power-law (PL) model. The X-ray flux densities of PL components for the eastern and western lobes at 1 keV are derived as 77.7 +28.9 −31.9 nJy and 52.4 +42.9 −42.4 nJy, respectively, and the photon indices are 1.69 +0.07 −0.13 and 1.84 +2.90 −0.12 , respectively. The non-thermal component is considered to be produced via the inverse Compton (IC) process, as is often seen in the X-ray emission from radio lobes. From a re-analysis of radio observation data, the multiwavelength spectra strongly suggest that the seed photon source of the IC X-rays includes both cosmic microwave background radiation and synchrotron radiation from the lobes. The derived parameters indicate significant dominance of the electron energy density over the magnetic field energy density in the Cygnus A lobes under the rich ICM environment.
CH-EUS has the potential to improve the preoperative diagnostic accuracy and inter-observer agreement in the differential diagnosis of GB wall thickening.
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