A label-free biological sensor, which is based on the resonant transmission phenomenon of a thin metallic mesh, is proposed in the terahertz wave region. By using this sensor, we demonstrate the highly sensitive detection of small amounts of protein horseradish peroxidase. For quantitative investigation of the sensitivity of our sensor, horseradish peroxidase was printed on the metallic mesh surface by using a commercial available printer. A distinct shift of the transmission dip frequency is observed for 500pg∕mm2 (11fmol) of horseradish peroxidase printed on the metallic mesh, indicating the significantly high sensitivity of our sensor.

Terahertz quantum cascade laser sources with intra-cavity non-linear frequency mixing are the first room-temperature electrically pumped monolithic semiconductor sources that operate in the 1.2–5.9 THz spectral range. However, high performance in low-frequency range is difficult because converted terahertz waves suffer from significantly high absorption in waveguides. Here, we report a sub-terahertz electrically pumped monolithic semiconductor laser. This sub-terahertz source is based on a high-performance, long-wavelength (λ ≈ 13.7 μm) quantum cascade laser in which high-efficiency terahertz generation occurs. The device produces peak output power of 11 μW within the 615–788 GHz frequency range at room temperature. Additionally, a source emitting at 1.5 THz provides peak output power of 287 μW at 110 K. The generated terahertz radiation of <2 THz is mostly attributable to the optical rectification process in long-wavelength infrared quantum cascade lasers.

In this work, we demonstrate a single-mode 1.0 THz quantum-cascade laser source with difference-frequency generation. The room temperature electrically pumped monolithic source is based on a long-wavelength dual-upper-state active region, in which high MIR to THz conversion efficiency is obtained. A two-section buried distributed feedback grating configuration with two different lengths is used to produce two single-mode MIR pumps, and as a result, the device exhibits single-mode THz emission with a side mode suppression ratio of ∼25 dB, at a frequency of 1.03 THz. A peak output power of 18 μW, with a high conversion efficiency of ∼270 μW W−2 is obtained at room temperature.

BackgroundIt is known that emotion regulatory responses of humans are changed by the experiences they have, but in particular, they are changed by becoming a mother. A recent study has found how a woman’s emotion regulatory response to a child’s crying changes after becoming a mother. However, mothers’ emotion regulatory responses other than those to children and the association between emotion regulatory response and parental stress are still unknown.MethodsEighteen healthy Japanese females (nine mothers and nine non-mothers) participated in the experiment. They performed an emotional Go/Nogo task, with facial expressions of others (angry, happy, and neutral faces) used as emotional stimuli. The percentage of correct responses, response time, and event-related potentials (ERPs) during the task was measured.ResultsThis comparison revealed that the mother group had a larger P3 (Nogo-P3) amplitude than the non-mother group when Nogo trials were held. This indicates that in mothers, there was greater activation of the behavioral inhibition-related brain areas than in non-mother women when they inhibited inappropriate behavior following recognition of facial expressions of others. In addition, in the mother group, there was a negative correlation between parental stress levels and Nogo-P3 amplitudes evoked by angry faces. This suggests that there is a relation between the level of parental stress of mothers and their emotion regulatory responses to angry faces.ConclusionsOur results demonstrate that mothers’ emotion regulatory processes may differ from those of non-mothers in response, not only to a child’s crying but also to expressions of emotions by others, and also suggest that the inhibitory recognition activity of mothers can be affected by parental stress.

Room-temperature terahertz (THz) quantum cascade laser sources with intracavity difference-frequency nonlinear mixing are electrically pumped monolithic semiconductor laser sources operating in the 0.6–6 THz spectral range. We report widely tunable, low-frequency THz quantum cascade laser sources using a lens-coupled Cherenkov waveguide scheme. Based on a watt-class high-power, λ ∼ 13.7    μm quantum cascade laser, the monolithic THz source is strongly coupled with a high-resistivity silicon lens, which causes a major increase in the THz coupling efficiency and demonstrates significant performance improvements. A room-temperature 1.5 THz device produces a 0.2 mW peak output power with a high-quality beam pattern. Improved THz outcoupling efficiency using the lens-coupled scheme enabled the demonstration of a high-performance external-cavity semiconductor THz source that is tunable from 420 GHz to 2 THz. The external-cavity, lens-coupled device configuration can technically be assembled into a butterfly-style package for a thumb-sized, widely frequency tunable THz semiconductor source.

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Dielectrophoretic (DEP) manipulation of a diamond particle has potential application in the detection of DNA or other bio-molecules. We investigate the fundamental DEP and surface properties of submicron diamond particles. Diamond particles were dispersed in a NaCl solution and dropped on a castle-walled electrode. An AC electric field was applied to determine the DEP crossover frequency as a function of the solution conductivity. The surface conductance of the diamond particles was then evaluated from the parametrical fitting of the crossover frequencies. The diamond surface layer was shown to exhibit a rather high conductance, although bulk diamond is insulative.

Background Child maltreatment is a major health and social welfare problem, with serious and longstanding consequences. Impulse control ability plays an important role in reducing the risk of child maltreatment. The aim of this study was to investigate the associations of oxytocin (OXT) and prolactin (PRL) with behavior inhibition using children’s facial expressions (angry or neutral) as emotional distractions. This may clarify a part of the neuroendocrinological mechanism that modulates impulse control ability in the context of child caregiving. Methods Participants were 16 females who had never been pregnant. Following venous blood sampling for OXT and PRL levels, participants performed an emotional Go/Nogo task during their follicular and luteal phases to test inhibitory control ability. Behavioral performance and event-related potentials (ERPs) during the task were measured. Results The results showed that there were significant fixed effects of OXT on behavioral performance, as measured by sensitivity (d-prime). This suggests that high peripheral OXT levels may be associated with better performance on the emotional Go/Nogo task, regardless of emotional distractors. PRL was associated with inhibitory processes as reflected by the Nogo-N2 and Nogo-P3. Particularly, high PRL levels were associated with the Nogo-N2 latency extension with the emotional distractors. Conclusions Our findings suggest that OXT might be associated with improving behavioral performance regardless of emotional processes. It is suggested that processes related to PRL are related to premotor activities of behavioral inhibitions and emotions.