2015): A prototype of aerial radiation monitoring system using an unmanned helicopter mounting a GAGG scintillator Compton camera, Journal of Nuclear Science and Technology, Due to the accident of Fukushima Daiichi Nuclear Power Plant, some areas were contaminated by released radioisotopes (mainly 137 Cs and 134 Cs). Effective decontamination is demanded to encourage evacuated people to return. This paper proposes a new survey system using an unmanned helicopter equipped with a Compton camera for localizing radionuclides. As a prototype, 32 Ce:Gd 3 (Al,Ga) 5 O 12 (GAGG) crystals were coupled to 16 silicon photomultipliers and 16 avalanched photodiodes as the scatterer and absorber, respectively. A new Dynamic Time-over-Threshold (dToT) method was applied to convert CR-RC shaping signals to digital signals for multi-channel spectra and coincidence acquisition. The system was designed to work in two modes: one is Compton-camera mode (CCM) which obtains the radiation distribution maps through Compton imaging using hovering flights, while the other one is Gamma-camera mode (GCM) which maps the radiation distribution via measured coincidence events using programmed flights. For point source in CCM, an intrinsic efficiency of 1.68% with a combined standard uncertainty of 0.04% and an angular resolution of about 14 • (FWHM, full width at half maximum) was achieved. In GCM, a spatial resolution of about 11 cm (FWHM) was obtained when detecting area is 11.2 cm away from the detector, while it was about 28 cm (FWHM) in single detector mode (SDM). Promising results were obtained in field in Fukushima.

The results of the present study suggest that inhibition of IL-6 signaling may become a preventive therapeutic option for breast cancer and bone metastases.

Background: Osteosarcoma is the most common primary malignancy of bone, and patients often develop pulmonary metastases. In a previous study, tumor necrosis factor (TNF)-α treatment of human osteosarcoma cells increases their metastatic ability in an animal model. TNF-α can act as a tumor necrosis factor and also as a tumor-promoting factor. In the present study, the effect of a TNF-α inhibitor on osteosarcoma aggressiveness and pulmonary metastases was investigated in vitro and in vivo. Methods: The effect of infliximab, a TNF-α inhibitor, on a metastatic osteosarcoma 143B cell growth and motility was investigated in vitro. An orthotopic xenograft model of 143B cell growth and spontaneous metastasis in SCID mice was used to assess the in vivo effect of infliximab. Results: Infliximab greatly reduced cell motility and pulmonary metastases in 143B cells. The mechanism of pulmonary metastasis inhibition involved decreased expression of CXC chemokine receptor 4 (CXCR4), Rho (small GTPase protein), and its effector. Conclusions: These results suggest a novel role for TNF-α inhibition in the reduction or prevention of pulmonary metastases of osteosarcoma in this animal model. TNF-α inhibition may become a preventive therapeutic option for the pulmonary metastases of osteosarcoma. © 2014 S. Karger AG, Basel

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