Background The rapid spread of novel coronavirus called SARS-CoV-2 or nCoV has caused countries all over the world to impose lockdowns and undertake stringent preventive measures. This new positive-sense single-stranded RNA strain of coronavirus spreads through droplets of saliva and nasal discharge. Purpose US FDA has authorized the emergency use of Remdesivir looking at the increasing number of cases of COVID-19, however there is still no drug approved to treat COVID-19. An alternative way of treatment could be the use of naturally derived molecules with known antiviral properties. Method We reviewed the antiviral activities of two polyphenols derived from tea, epigallocatechin-3-gallate (EGCG) from green tea and theaflavins from black tea. Both green tea and black tea polyphenols have been reported to exhibit antiviral activities against various viruses, especially positive-sense single-stranded RNA viruses. Results Recent studies have revealed the possible binding sites present on SARS-CoV-2 and studied their interactions with tea polyphenols. EGCG and theaflavins, especially theaflavin-3,3′-digallate (TF3) have shown a significant interaction with the receptors under consideration in this review. Some docking studies further emphasize on the activity of these polyphenols against COVID-19. Conclusion This review summarizes the available reports and evidences which support the use of tea polyphenols as potential candidates in prophylaxis and treatment of COVID-19.

No abstract

No abstract

No abstract

This chapter presents an overview of various complementary nutritional approaches for the management of brain disorders. Numerous epidemiological studies emphasize the growing burden of brain disorders worldwide. Due to the complex pathophysiology, lack of precise diagnostic and therapeutic options, there is growing need to have alternative approaches. One important strategy for the prevention and treatment of brain impairment is based on dietary supplements, functional foods, and nutraceuticals. The current chapter illustrates various aspects of available nutritional products for the brain disorder. Considering the recent surge in the nutritional products and as it destined to play an important role in future, existing regulatory framework is explained here which ensures purity, safety, and efficacy of the marketed products.