Hyperimmunoglobulinemia E (Job's) syndrome is characterized by markedly increased levels of immunoglobulin E, recurrent cutaneous and systemic pyogenic infections, atopic dermatitis, and peripheral eosinophilia. Although ocular involvement in Job's syndrome is rare, there are reports of keratoconus, staphylococcal chalazia with blepharitis, and Candida endophthalmitis by various authors. We present the first case report of retinal detachment with complicated cataract in Job's syndrome.

No abstract

BACKGROUND: The prevalence of type 2 diabetes is known to be very high in the Indian subcontinent. Indian patients demonstrate certain distinct features i.e., onset at a younger age, a strong genetic predisposition and less common obesity. It is estimated that 79.4 million people in India will have Diabetes by the year 2030. The rapid increase in the number of persons with Diabetes is expected to lead to an increase in the number of persons with ocular complications of diabetes. Few studies have reported the magnitude and distribution of diabetic retinopathy (DR) in India. Diabetes mellitus (DM) is a major cause of avoidable blindness in both the developing and the developed countries. Patients with diabetic retinopathy (DR) are 25 times more likely to become blind than non-diabetics. Studies of various complications in Indian diabetics is therefore of great interest and very few studies are available on the prevalence of diabetic retinopathy from India. This study aims to estimate the prevalence of Diabetic Retinopathy in type 2 diabetes and the possible risk factors associated with DR. OBJECTIVES: To estimate the prevalence of Diabetic Retinopathy (DR) and the possible risk factors associated with DR METHODS: Source of Data The materials for the present study will be drawn from patients attending the outpatient department of Ophthalmology at Chigateri General Hospital and Bapuji Hospital attached to J.J.M Medical College, Davangere from November 2010 to September 2012. Method of collection of Data (including sampling procedures if any): A minimum of 100 cases with Type 2 Diabetes in CG hospital and Bapuji Hospital, Davangere will be selected for the study. A careful and detailed history will be taken regarding the duration and symptoms of the disease. Thorough systemic examination will be done. Investigations like routine blood, urine examination, FBS/PLBS and Lipid Profile will be done. This will be followed by a detailed Eye examination including: Examination of adnexae and extraocular structures i.e. the examination of face, orbits, eyebrows, eyelids, palpebral fissure, extraocular movements and lacrimal sac. Examination of anterior segment by slit lamp biomicroscopy Examination of the posterior segment by ophthalmoscopy (direct and indirect) and +90D biomicroscopy. Fundus Photography followed by Fluorescein Angiography (if required) will be undertaken for positive cases. Recording of visual acuity and intraocular pressure (applanation) will be done. RESULTS: A total of 1711 patients (M: 941, F: 770) were screened and 223 type 2 diabetic patients were enrolled in the study (137 males (61.4%) 86 females (38.6%). The Mean age was 55.92 + 10.027 (Males: 56.12 + 10.218 years and females: 55.73 + 9.836 years). Mean duration of Diabetes was 6.83 + 5.694. Prevalence of Type 2 Diabetes among the study population was 13.03 %. (17.03% for males and 11.16% for females).The Prevalence of Diabetic Retinopathy among type 2 diabetic was 30.49% (68out of 223 patients). Male preponderance was present among DR patients (40cas...

Background: Hereditary genodermatoses are characterized by propensity to develop malignancies in cutaneous and ocular structures. Objective: To document in a series of patients with oculocutaneous albinism and xeroderma pigmentosa the histological spectrum of malignant oculocutaneous tumors. Materials and Methods: Biopsies from 6 patients were subjected to histopathological examination for tumor type. Results: A diagnosis of basosquamous cell carcinoma (BSCC) was made in 3 cases, basal cell carcinoma (face) and BSCC (neck) in one, ocular surface squamous neoplasia and SCC in one case each. Conclusion: In the background of genodermatoses, importance of regular and careful follow-up to detect and treat malignancies at an early stage is needed.

Introduction: Basal cell carcinoma (BCC) is a common example of basaloid tumor accounting for approximately 70% of all skin cancers. Periocular skin and eyelids are common sites of neoplastic lesions of the head and neck. Even though BCC is a slowly growing tumor with no metastases, it poses a threat in the periocular region due to its closeness to vital structures. Materials and Methods: The study comprised periocular BCCs diagnosed from July 2011 to June 2016. Clinical details were collected for the specimens. Microscopic findings were analyzed on hemotoxylin and eosin stained sections. Results: Of the 123 periocular tumors in a period of 5 years, 27 were malignant epithelial tumors. Of these, 23 cases were BCC, common in females (20 cases), and the most common age group was 60-69 followed by 70-79 years. Most common presentation was an ulcerated lesion and 31.8% of the lesions were in the medial canthus. Conclusion: All our cases were periocular lesions, so they were of high risk. Two patients were genetically predisposed and younger than 40 years, and two patients had recurrences. The referral patterns will be influenced by the concept of risk type (low or high) for BCC. Identification of lesions at the earliest can reduce the associated morbidity and recurrences.