We study the partial decay widths of the charmonium states (J/ψ, ψ(3686), ψ(3770), χ c0 , χ c2 ) to DD (D + D − or D 0D0 ) in isospin asymmetric nuclear matter, in the presence of strong magnetic fields.The in-medium partial decay widths of charmonium states to DD are calculated within a light quarkantiquark pair creation model, namely the 3 P 0 model, using the in-medium masses of the charmonia as well as D andD mesons in the magnetized nuclear matter, obtained within a chiral effective model.The presence of a magnetic field leads to Landau quantization of the energy levels of the proton in the nuclear medium. The effects of magnetic field and isospin asymmetry on the charmonium decay widths to DD are found to be quite prominent. The effects of the anomalous magnetic moments have also been taken into consideration for obtaining the in-medium masses of these heavy flavour mesons, used to calculate the partial decay widths of the charmonium states. The medium modifications of the charmonium decay widths can have observable consequences on the production of the charmed mesons in high energy asymmetric heavy ion collision experiments.
Background:
The present study was intended to comparatively assess the efficacy of ganglioside polymeric nanoparticle-coated 0.25% satranidazole-loaded nanoparticles in gel form with that of the commercially available 1% metronidazole gel as a local drug delivery (LDD) agent for the treatment of periodontal pockets.
Materials and Methods:
A split-mouth randomized clinical trial was carried out in 46 chronic periodontitis patients with probing pocket depth (PPD) ≥4 mm or clinical attachment loss greater than 3 mm on both quadrants of the same arch. Full-mouth scaling and root planing (SRP) was performed for all the patients followed by application of 0.25% satranidazole-loaded nanoparticles in gel form on one site (Group 1) and commercially available 1% metronidazole gel on another site (Group 2). Clinical parameters (gingival index, plaque index, PPD, clinical attachment level gain, and bleeding on probing) and microbiological analysis of the subgingival plaque samples were performed and assessed at baseline, after SRP, 21st day, and 90th day post treatment. Unpaired “t”-test and ANOVA tests were used for intergroup and intragroup comparison of recorded parameters.
Results:
The results showed that the satranidazole-loaded nanoparticle group as an adjunct to SRP in chronic periodontitis showed a statistically significant improvement in all the clinical parameters and a fewer relapse of microbial flora in comparison with the metronidazole group as an LDD agent.
Conclusion:
The present study depicted that both the LDD agents showed an effective improvement of clinical as well as microbiological parameters, but the satranidazole group consistently produced better results than the metronidazole group and hence has a promising future as an LDD agent in treating periodontal pockets.
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