Cattle domestication and the complex histories of East Asian cattle breeds warrant further investigation. Through analysing the genomes of 49 modern breeds and eight East Asian ancient samples, worldwide cattle are consistently classified into five continental groups based on Y-chromosome haplotypes and autosomal variants. We find that East Asian cattle populations are mainly composed of three distinct ancestries, including an earlier East Asian taurine ancestry that reached China at least ~3.9 kya, a later introduced Eurasian taurine ancestry, and a novel Chinese indicine ancestry that diverged from Indian indicine approximately 36.6–49.6 kya. We also report historic introgression events that helped domestic cattle from southern China and the Tibetan Plateau achieve rapid adaptation by acquiring ~2.93% and ~1.22% of their genomes from banteng and yak, respectively. Our findings provide new insights into the evolutionary history of cattle and the importance of introgression in adaptation of cattle to new environmental challenges in East Asia.

Abstract-This paper studies the solution of joint energy storage (ES) ownership sharing between multiple shared facility controllers (SFCs) and those dwelling in a residential community. The main objective is to enable the residential units (RUs) to decide on the fraction of their ES capacity that they want to share with the SFCs of the community in order to assist them storing electricity, e.g., for fulfilling the demand of various shared facilities. To this end, a modified auction-based mechanism is designed that captures the interaction between the SFCs and the RUs so as to determine the auction price and the allocation of ES shared by the RUs that governs the proposed joint ES ownership. The fraction of the capacity of the storage that each RU decides to put into the market to share with the SFCs and the auction price are determined by a noncooperative Stackelberg game formulated between the RUs and the auctioneer. It is shown that the proposed auction possesses the incentive compatibility and the individual rationality properties, which are leveraged via the unique Stackelberg equilibrium (SE) solution of the game. Numerical experiments are provided to confirm the effectiveness of the proposed scheme.

A recently developed adenine base editor (ABE) efficiently converts A to G and is potentially useful for clinical applications. However, its precision and efficiency in vivo remains to be addressed. Here we achieve A-to-G conversion in vivo at frequencies up to 100% by microinjection of ABE mRNA together with sgRNAs. We then generate mouse models harboring clinically relevant mutations at Ar and Hoxd13, which recapitulates respective clinical defects. Furthermore, we achieve both C-to-T and A-to-G base editing by using a combination of ABE and SaBE3, thus creating mouse model harboring multiple mutations. We also demonstrate the specificity of ABE by deep sequencing and whole-genome sequencing (WGS). Taken together, ABE is highly efficient and precise in vivo, making it feasible to model and potentially cure relevant genetic diseases.

Abstract-This paper proposes a novel electric vehicle (EV) classification scheme for a photovoltaic (PV) powered EV charging station (CS) that reduces the effect of intermittency of electricity supply as well as reducing the cost of energy trading of the CS. Since not all EV drivers would like to be environmentally friendly, all vehicles in the CS are divided into three categories: 1) premium, 2) conservative, and 3) green, according to their charging behavior. Premium and conservative EVs are considered to be interested only in charging their batteries, with noticeably higher rate of charging for premium EVs. Green vehicles are more environmentally friendly, and thus assist the CS to reduce its cost of energy trading by allowing the CS to use their batteries as distributed storage. A different charging scheme is proposed for each type of EV, which is adopted by the CS to encourage more EVs to be green. A basic mixed integer programming (MIP) technique is used to facilitate the proposed classification scheme. It is shown that the uncertainty in PV generation can be effectively compensated, along with minimization of total cost of energy trading to the CS, by consolidating more green EVs. Real solar and pricing data are used for performance analysis of the system. It is demonstrated that the total cost to the CS reduces considerably as the percentage of green vehicles increases, and also that the contributions of green EVs in winter are greater than those in summer.

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