Mass-examination of all 31 employees of a chemical factory revealed that 20 of them were proved or suspected to have contact hypersensitivities to chemical substances used in the factory as follows: 12 cases were sensitive to 2-amino-4-chlorophenol, 5 to para-aminophenol, 2 to paradichloronitrobenzene, and 1 to para-nitrophenol. Among the 5 compounds tested (including the above 4 substances and 3' -chlorodiphenylamine-2-carboxylic acid), 2-amino-4-chlorophenol was found to be an especially strong sensitizer,
Using guinea pigs sensitized with 2-amino-4-chlorophenol, cross sensitization between this compound and para-aminophenol derivatives was studied. The results of the patch test showed no evidence of cross sensitization; however, the leucocyte adherence inhibition test suggested that cross sensitization may occur.
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