Male breast cancer occurs rarely, comprising <1% of breast cancers. Due to the low incidence of male breast cancer, clinical trials of this disease are lacking. Therefore, therapeutic strategies utilized in the management of female breast cancer are often applied to male patients with breast cancer. Specifically, clinical outcomes using CDK 4/6 inhibitors require further investigation in male patients. To the best of our knowledge, the present report presents the first known case of a male patient treated with second line Abemaciclib, Lupron and Fulvestrant, producing complete remission. To the best of our knowledge this is also the first report of complete remission in a male breast cancer patient with a regimen utilizing a CDK 4/6 inhibitor. Case report We present a case of a 39 year old male with no past medical history who initially palpated a mass in his left breast in March 2015. A diagnostic mammogram and left breast ultrasound showed an irregular mass measuring 9x7x7 mm in the outer left breast at 3 o'clock suspicious for malignancy. In March 2015 he underwent left mastectomy with pathology demonstrating grade II infiltrating ductal carcinoma, 1.6 cm
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