Introduction: Serum amylase level can rise asymptomatically after endoscopic retrograde cholangiopancreatography (ERCP). Thus, its assay can lead to overprediction of post-ERCP pancreatitis (PEP). Lipase assay is used to diagnose other forms of pancreatitis but usually not for PEP. Objectives: The aim of this study was to predict whether lipase may be of better use for the early prediction of PEP. Methods: One hundred and twenty-five consecutive ERCPs performed over a period of 1 year and 9 months were observed. On admission (baseline) and after ERCP at 4 and 24 h, serum amylase and lipase were measured. Based on sensitivity and specificity from the receiver operator characteristic (ROC) curve, optimal cutoff levels for the enzyme, serum lipase, and amylase levels were employed to predict PEP. Results: Out of 125 patients, 26 (20.8%) developed PEP. In multivariate analysis, young age, suspected sphincter of Oddi dysfunction, recurrent pancreatitis, and needle papillotomy were significant risk factors. Considering the optimum cutoff level (single value with the best sensitivity and specificity), both the enzyme amylase and lipase evaluated at 4 h were significant (Chi-square test: P =0.0001 for both the enzymes). However, multivariate regression analysis and levels of enzymes at different cutoff values in the ROC found that 4-h lipase levels were more (about 4 times) increased of the upper limit of normal range than amylase levels (1.19 times). Conclusion: The enzyme, serum amylase, and lipase evaluated at 4 h after ERCP were satisfactory predictors for PEP. However, when compared, serum lipase was more reliable than amylase.
Background: Esophageal variceal bleeding is a potentially fatal complication in patients with liver cirrhosis and portal hypertension. In cirrhotic patients, endoscopic screening for esophageal varices (EV)is currently recommended at the time of diagnosis. The present study intends to find out correlation between platelet countspleen bipolar diameter ratio and esophageal varices in liver cirrhosis and prospectively validate its use for the noninvasive diagnosis of EV.Methods: This observational study was done at theDepartment of Gastrointestinal Hepatobiliary and Pancreatic Disorder, BIRDEM General Hospital, Dhaka, during the period of November, 2013 to October, 2014. A total 64 patients with cirrhosis of liver were included. Complete blood count, liver function tests, ultrasonographyof whole abdomenand endoscopy of upper gastro-intestinal tract (GIT)were done in all patients. Statistical analysis was done with SPSS version 16.Results: Among 64 study population EV were detected in 54 patients (84.4%). The platelet count/ spleen bipolar diameter ratio was significantly higher without EV compared with those with EV(1570 ± 493) and (688 ± 227), respectively; (p<0.001).Patients with EV had lower platelet counts (86799.84 ±27389.99/mm3, p<0.001), higher bipolar spleen diameters (127.94±15.14 mm, p<0.001) and lower platelet count/ spleen bipolar diameter ratios (688.79 ±227.13, p<0.001). In this analysis, by applying (ROC)curve the platelet count-spleen bipolar diameter ratio at a cut-of 908.5 maintained high sensitivity (100 %), Robust negative predictive value NPV (100%),specificity (55.6%) and PPV (85.4%), with an overall diagnostic accuracy of 87.50% for the prediction of EV.With advancing Child-Pugh (C-P) class the percentage of patients with varices increased, 33.3% in C-P class A, 85.7% in C-P class B and 91.6% in C-P class C. The presence of EVcorrelated significantly with the severity of liver cirrhosis (p = 0.03) as measured by Child-Pugh score.Conclusion: The identification of non-endoscopic, noninvasive methods that can accurately predict esophageal varicesin cirrhosis of liver has been addressed in several recent studies. This study was yet another attempt to achieve this goal. Predicting the presence of EV by noninvasive means would restrict the performance of endoscopy and reducing the number of unpleasant screening endoscopiesBirdem Med J 2018; 8(2): 159-166
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