lesions involving the appendix and were included. Six patients had prior appendectomy. Lesions had a mean % circumferential appendiceal orifice involvement of 66AE29%, with 19 (34%) lesions spread laterally beyond the orifice. The mean estimated pre-resection lesion size was 13AE6mm. Lesions were mostly of Is 25 (45%) and IIa 20 (36%) Paris class. Out of 14 patients with a prior resection attempt, 4 failed resection, 6 had macroscopic residual, 2 had microscopic residual, and 2 had recurrence. Majority of patients were sedated by propofol and received pre-procedural antibiotics (85%). Technical success was achieved in 53 (95%) patients. Of 3 technical failures, 2 were managed by cold forceps avulsion and 1 by hot snare resection. Mean procedure duration was 61AE24 minutes and median length of hospital stay was 1 day. Post EFTR antibiotics were given in 43/53 (81%) patients for a median of 5 days. R0 resection was achieved in 49/53 (92%) cases. Out of the 47 successful EFTR cases and with no prior appendectomy, 9 (19%) patients were diagnosed with appendicitis (majority had received antibiotics, Table 1) after a median of 6 days post-operatively (2 were complicated by perforation and 1 by abscess).Three patients were managed with intravenous antibiotics alone and 6 underwent appendectomy. Follow-up colonoscopy in 19/53 (36%) patients at a median of 152 days showed no evidence of residual lesions. On univariable analysis (Table 1), post resection orifice patency (pZ0.03), smaller resected specimen diameter (pZ0.04), and depth (pZ0.02) were associated with lower rate of appendicitis. Conclusion: FTRD is a relatively safe and feasible method for appendiceal lesion resection but appendicitis occurs in 1 out of 5 cases. Smaller lesion size might contribute to lower rate of appendicitis. Antibiotics do not seem to have a role in the prevention of appendicitis.Large cecal polyp. Endoluminal therapetic platform is preloaded on the endoscope and its handle can be seen next to the patient
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