Topical or oral azole antifungals are commonly used in canine atopic dermatitis
(AD), as the lipophilic yeast Malassezia pachydermatis exacerbates canine
AD. To examine whether canine AD lesions harbor azole-resistant M.
pachydermatis isolates in East Asia, we investigated the in
vitro susceptibility of M. pachydermatis isolates to
ketoconazole (KTZ) and itraconazole (ITZ) obtained from AD lesions of canines in Japan,
Korea and Taiwan. The minimum inhibitory concentrations (MICs) of KTZ and ITZ were
measured by the E-test using Sabouraud dextrose agar with 0.5% Tween 40. The MICs of KTZ
and ITZ for isolates from canines with AD were significantly higher than the MICs for
isolates from healthy canines. Our findings suggested that the clinical isolates from
canine AD skin lesions were less susceptible to azoles than those from normal canine skin
in East Asia.
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